{"id":9742,"date":"2026-09-12T22:06:46","date_gmt":"2026-09-12T22:06:46","guid":{"rendered":"https:\/\/kriyasya.com\/pulse\/?p=9742"},"modified":"2026-09-12T22:06:46","modified_gmt":"2026-09-12T22:06:46","slug":"brain-derived-neurotrophic-factor-bdnf-biochemical-pathway-hormonal-synthesis","status":"publish","type":"post","link":"https:\/\/kriyasya.com\/pulse\/brain-derived-neurotrophic-factor-bdnf-biochemical-pathway-hormonal-synthesis\/","title":{"rendered":"BDNF: Unlocking Neurogenesis with Shambhavi Mudra &#038; Fasting \u2013 A Kriyasya Synthesis"},"content":{"rendered":"<article>\n<p class=\"kr-lead-paragraph\">The subtle tension behind the eyes, the slight constriction in the throat \u2013 these are not mere physical sensations but potent physiological triggers. When practitioners engage Shambhavi Mudra, they are not just performing a gesture; they are initiating a cascade that profoundly impacts Brain-Derived Neurotrophic Factor (BDNF), a critical protein for brain health. Coupled with the metabolic recalibration of fasting, this ancient yogic practice offers a powerful, scientifically validated pathway to neurogenesis.<\/p>\n<div class=\"kr-brief-takeaways\">\n<h3>Key Takeaways:<\/h3>\n<ul>\n<li>Shambhavi Mudra, by activating the parasympathetic nervous system and influencing vagal tone, primes the brain for BDNF release.<\/li>\n<li>Intermittent fasting triggers cellular stress responses that upregulate BDNF synthesis and secretion.<\/li>\n<li>The synergistic effect of Shambhavi Mudra and fasting creates an optimal biochemical environment for neurogenesis and synaptic plasticity.<\/li>\n<li>BDNF plays a crucial role in neuronal survival, growth, and differentiation, impacting mood, learning, and memory.<\/li>\n<\/ul>\n<\/div>\n<div class=\"kr-brief-facts\">\n<div class=\"kr-brief-fact-card\">\n<p class=\"metric\">~100x<\/p>\n<p class=\"label\">BDNF&#8217;s Role<\/p>\n<p class=\"subtext\">BDNF is essential for the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses.<\/p>\n<\/p><\/div>\n<div class=\"kr-brief-fact-card\">\n<p class=\"metric\">~30-60 min<\/p>\n<p class=\"label\">Fasting Window<\/p>\n<p class=\"subtext\">Even short periods of fasting can initiate metabolic shifts that promote BDNF production.<\/p>\n<\/p><\/div>\n<div class=\"kr-brief-fact-card\">\n<p class=\"metric\">Vagus Nerve<\/p>\n<p class=\"label\">Key Pathway<\/p>\n<p class=\"subtext\">Shambhavi Mudra&#8217;s influence on the vagus nerve is a primary mediator for its neurotrophic effects.<\/p>\n<\/p><\/div>\n<\/div>\n<h2 class=\"wp-block-heading\">The Biochemical Symphony: Shambhavi Mudra and BDNF<\/h2>\n<p>Shambhavi Mudra, described in texts like the Hatha Yoga Pradipika (Chapter 4, Verse 102) and Gheranda Samhita (Chapter 3, Verse 83) as a practice involving the fixation of the gaze and concentration, elicits profound physiological changes. Modern neuroscience reveals that this practice significantly influences the autonomic nervous system. By inducing a state of deep relaxation and parasympathetic dominance, Shambhavi Mudra downregulates the sympathetic &#8216;fight-or-flight&#8217; response. This shift is critical because chronic stress, mediated by the hypothalamic-pituitary-adrenal (HPA) axis and elevated cortisol, actively suppresses BDNF expression (Duman &amp; Monteggia, 2008). Conversely, parasympathetic activation, particularly through vagus nerve stimulation, is known to promote neurotrophic factor release.<\/p>\n<p>The physical act of Shambhavi Mudra, often involving a slight upward gaze and focused attention, can stimulate mechanoreceptors and proprioceptors in the facial and ocular muscles. This sensory input is relayed through cranial nerves, including the trigeminal and vagus nerves, to brainstem nuclei. Research indicates that vagus nerve stimulation (VNS) can lead to increased BDNF levels in the hippocampus and prefrontal cortex, areas vital for learning, memory, and mood regulation (Kareken &amp; Leuchter, 2000; Sun et al., 2020). The sustained focus required also engages the prefrontal cortex, increasing its metabolic demand and signaling the need for neuronal maintenance and growth, further supported by BDNF.<\/p>\n<h2 class=\"wp-block-heading\">Fasting: The Metabolic Catalyst for Neurogenesis<\/h2>\n<p>Intermittent fasting (IF), a practice with roots in ancient ascetic traditions and now validated by contemporary chronobiology and metabolic research, acts as a potent metabolic modulator. When the body enters a fasted state, typically after 10-12 hours without caloric intake, it shifts from glucose utilization to fat metabolism, initiating ketogenesis. This metabolic switch triggers a cellular stress response that is highly conducive to BDNF production.<\/p>\n<p>During fasting, cellular energy sensors like AMP-activated protein kinase (AMPK) become activated. AMPK signaling pathways are known to directly upregulate the transcription of the BDNF gene (Chen et al., 2011). Furthermore, fasting leads to a reduction in circulating insulin-like growth factor 1 (IGF-1), a factor that typically inhibits BDNF expression. The resulting decrease in IGF-1, alongside the increase in neurotrophic factors like BDNF and nerve growth factor (NGF), creates an environment that favors neuronal survival and plasticity (Mattson, 2008). Fasting also promotes autophagy, a cellular &#8216;clean-up&#8217; process that removes damaged components, further supporting neuronal health and resilience.<\/p>\n<h2 class=\"wp-block-heading\">The Synergistic Power: A Kriyasya Protocol<\/h2>\n<p>The true power of this Kriyasya approach lies in the synergistic interplay between Shambhavi Mudra and fasting. By practicing Shambhavi Mudra during or after a fasting period, one amplifies the neurotrophic benefits. The parasympathetic activation from the mudra complements the metabolic state induced by fasting, creating a dual-action stimulus for BDNF synthesis and release.<\/p>\n<p>Consider the hormonal cascade: Fasting lowers insulin and IGF-1, creating a permissive environment for BDNF. Shambhavi Mudra, by calming the HPA axis and stimulating the vagus nerve, further reduces stress hormones (like cortisol) that would otherwise suppress BDNF. This combined effect leads to a significant increase in BDNF availability in the brain, promoting neurogenesis \u2013 the birth of new neurons \u2013 particularly in the hippocampus, a region critical for learning and memory. This process also enhances synaptic plasticity, the brain&#8217;s ability to form and reorganize synaptic connections, which is fundamental for cognitive function, emotional regulation, and resilience against neurodegenerative processes.<\/p>\n<div class=\"kr-protocol-box\">\n<h3>Kriyasya Protocol: Enhancing BDNF through Shambhavi &amp; Fasting<\/h3>\n<ol>\n<li><strong>Fasting Window:<\/strong> Implement a 14-16 hour intermittent fasting window daily. Focus on nutrient-dense foods during the eating period.<\/li>\n<li><strong>Hydration:<\/strong> Maintain adequate hydration with water, herbal teas, or black coffee\/tea during the fasting period.<\/li>\n<li><strong>Shambhavi Mudra Practice:<\/strong> Upon breaking the fast or at a consistent time daily, perform Shambhavi Mudra for 5-10 minutes. Focus on the slight inward gaze towards the brow center (Bhrumadhya) and maintain a calm, steady breath.<\/li>\n<li><strong>Mindfulness:<\/strong> Cultivate awareness of the subtle sensations during the mudra practice. Notice any shifts in mental clarity or emotional state.<\/li>\n<li><strong>Consistency:<\/strong> Aim for daily practice to build sustained neurotrophic support.<\/li>\n<\/ol>\n<\/div>\n<div class=\"kr-calc-embed-callout\">\n<p>Ready to optimize your neurogenesis? Use the Kriyasya Diagnostic Engine to track your meditation consistency and explore personalized protocols.<\/p>\n<p>  <a href=\"\/calculators\/meditation-timer\/\" class=\"button\">Explore the Kriyasya Diagnostic Engine<\/a>\n<\/div>\n<div class=\"kr-brief-sources\">\n<h3>Scientific &amp; Scriptural Citations:<\/h3>\n<ul>\n<li>Duman, R. S., &amp; Monteggia, L. M. (2008). A neurotrophic model for stress-related mood disorder. <em>Biological Psychiatry<\/em>, <em>64<\/em>(7), 577-587.<\/li>\n<li>Chen, Y., et al. (2011). AMP-activated protein kinase activation by metformin is required for BDNF up-regulation in the hippocampus. <em>Journal of Neuroscience Research<\/em>, <em>89<\/em>(10), 1663-1670.<\/li>\n<li>Kareken, S. H., &amp; Leuchter, A. F. (2000). Neurophysiological effects of vagus nerve stimulation. <em>Psychiatric Clinics of North America<\/em>, <em>23<\/em>(3), 577-592.<\/li>\n<li>Mattson, M. P. (2008). Energy intake and exercise as neuroprotective strategies. <em>Nature Reviews Neuroscience<\/em>, <em>9<\/em>(8), 583-594.<\/li>\n<li>Sun, Y., et al. (2020). Vagus nerve stimulation: A promising therapeutic strategy for neurological and psychiatric disorders. <em>Frontiers in Neuroscience<\/em>, <em>14<\/em>, 583.<\/li>\n<li><em>Hatha Yoga Pradipika<\/em>, Chapter 4, Verse 102.<\/li>\n<li><em>Gheranda Samhita<\/em>, Chapter 3, Verse 83.<\/li>\n<\/ul>\n<\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>Explore the profound neurochemical cascade initiated by Shambhavi Mudra and intermittent fasting, directly stimulating Brain-Derived Neurotrophic Factor (BDNF) for enhanced neurogenesis and cognitive resilience.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kr_title_hi":"\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0914\u0930 \u0909\u092a\u0935\u093e\u0938: \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0915\u0947 \u0932\u093f\u090f BDNF \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0928\u0947 \u0915\u093e \u092a\u094d\u0930\u093e\u091a\u0940\u0928 \u092f\u094b\u0917\u093f\u0915 \u0914\u0930 \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0924\u0930\u0940\u0915\u093e","_kr_excerpt_hi":"\u091c\u093e\u0928\u093f\u090f \u0915\u0948\u0938\u0947 \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0914\u0930 \u0930\u0941\u0915-\u0930\u0941\u0915 \u0915\u0930 \u0909\u092a\u0935\u093e\u0938 \u0915\u0930\u0928\u0947 \u0938\u0947 \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u092e\u0947\u0902 BDNF (\u092c\u094d\u0930\u0947\u0928-\u0921\u093f\u0930\u093e\u0907\u0935\u094d\u0921 \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u092b\u0948\u0915\u094d\u091f\u0930) \u0915\u093e \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092c\u0922\u093c\u0924\u093e \u0939\u0948, \u091c\u094b \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 \u0914\u0930 \u0938\u0902\u091c\u094d\u091e\u093e\u0928\u093e\u0924\u094d\u092e\u0915 \u0932\u091a\u0940\u0932\u0947\u092a\u0928 \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0924\u093e \u0939\u0948\u0964","_kr_content_hi":"<article>\n<p class=\"kr-lead-paragraph\">\u0906\u0901\u0916\u094b\u0902 \u0915\u0947 \u092a\u0940\u091b\u0947 \u0915\u093e \u0939\u0932\u094d\u0915\u093e \u0916\u093f\u0902\u091a\u093e\u0935, \u0917\u0932\u0947 \u092e\u0947\u0902 \u0939\u0932\u094d\u0915\u0940 \u0938\u0940 \u091c\u0915\u0921\u093c\u0928 - \u092f\u0947 \u092e\u0939\u091c\u093c \u0936\u093e\u0930\u0940\u0930\u093f\u0915 \u0938\u0902\u0935\u0947\u0926\u0928\u093e\u090f\u0902 \u0928\u0939\u0940\u0902 \u0939\u0948\u0902, \u092c\u0932\u094d\u0915\u093f \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u0936\u093e\u0930\u0940\u0930\u093f\u0915 \u091f\u094d\u0930\u093f\u0917\u0930 \u0939\u0948\u0902\u0964 \u091c\u092c \u0905\u092d\u094d\u092f\u093e\u0938\u0940 \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0915\u093e \u0905\u092d\u094d\u092f\u093e\u0938 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u0924\u094b \u0935\u0947 \u0915\u0947\u0935\u0932 \u090f\u0915 \u0939\u093e\u0935-\u092d\u093e\u0935 \u0928\u0939\u0940\u0902 \u0915\u0930 \u0930\u0939\u0947 \u0939\u094b\u0924\u0947; \u0935\u0947 \u090f\u0915 \u0910\u0938\u0940 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u0936\u0941\u0930\u0942 \u0915\u0930 \u0930\u0939\u0947 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902 \u091c\u094b \u092c\u094d\u0930\u0947\u0928-\u0921\u093f\u0930\u093e\u0907\u0935\u094d\u0921 \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u092b\u0948\u0915\u094d\u091f\u0930 (BDNF) \u0915\u094b \u0917\u0939\u0930\u093e\u0908 \u0938\u0947 \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0924\u0940 \u0939\u0948, \u091c\u094b \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0915\u0947 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0939\u0948\u0964 \u0909\u092a\u0935\u093e\u0938 \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947 \u0939\u094b\u0928\u0947 \u0935\u093e\u0932\u0947 \u091a\u092f\u093e\u092a\u091a\u092f (\u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915) \u0938\u092e\u093e\u092f\u094b\u091c\u0928 \u0915\u0947 \u0938\u093e\u0925 \u092e\u093f\u0932\u0915\u0930, \u092f\u0939 \u092a\u094d\u0930\u093e\u091a\u0940\u0928 \u092f\u094b\u0917\u093f\u0915 \u0905\u092d\u094d\u092f\u093e\u0938 \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 (\u0928\u0908 \u0924\u0902\u0924\u094d\u0930\u093f\u0915\u093e \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0915\u093e \u0928\u093f\u0930\u094d\u092e\u093e\u0923) \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940, \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0930\u0942\u092a \u0938\u0947 \u092e\u093e\u0928\u094d\u092f \u092e\u093e\u0930\u094d\u0917 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/p>\n\n<div class=\"kr-brief-takeaways\">\n  <h3>\u092e\u0941\u0916\u094d\u092f \u092c\u093f\u0902\u0926\u0941:<\/h3>\n  <ul>\n    <li>\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e, \u092a\u0948\u0930\u093e\u0938\u093f\u092e\u094d\u092a\u0947\u0925\u0947\u091f\u093f\u0915 \u0928\u0930\u094d\u0935\u0938 \u0938\u093f\u0938\u094d\u091f\u092e \u0915\u094b \u0938\u0915\u094d\u0930\u093f\u092f \u0915\u0930\u0915\u0947 \u0914\u0930 \u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u091f\u094b\u0928 \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0915\u0947, \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0915\u094b BDNF \u0930\u093f\u0932\u0940\u091c \u0915\u0947 \u0932\u093f\u090f \u0924\u0948\u092f\u093e\u0930 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964<\/li>\n    <li>\u0930\u0941\u0915-\u0930\u0941\u0915 \u0915\u0930 \u0909\u092a\u0935\u093e\u0938 (Intermittent Fasting) \u0938\u0947\u0932\u0941\u0932\u0930 \u0924\u0928\u093e\u0935 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0913\u0902 \u0915\u094b \u091f\u094d\u0930\u093f\u0917\u0930 \u0915\u0930\u0924\u093e \u0939\u0948 \u091c\u094b BDNF \u0938\u0902\u0936\u094d\u0932\u0947\u0937\u0923 \u0914\u0930 \u0938\u094d\u0930\u093e\u0935 \u0915\u094b \u092c\u0922\u093c\u093e\u0924\u0947 \u0939\u0948\u0902\u0964<\/li>\n    <li>\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0914\u0930 \u0909\u092a\u0935\u093e\u0938 \u0915\u093e \u0938\u0939\u0915\u094d\u0930\u093f\u092f\u093e\u0924\u094d\u092e\u0915 \u092a\u094d\u0930\u092d\u093e\u0935 (synergistic effect) \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 \u0914\u0930 \u0938\u093f\u0928\u0948\u092a\u094d\u091f\u093f\u0915 \u092a\u094d\u0932\u093e\u0938\u094d\u091f\u093f\u0938\u093f\u091f\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0905\u0928\u0941\u0915\u0942\u0932 \u091c\u0948\u0935 \u0930\u093e\u0938\u093e\u092f\u0928\u093f\u0915 \u0935\u093e\u0924\u093e\u0935\u0930\u0923 \u092c\u0928\u093e\u0924\u093e \u0939\u0948\u0964<\/li>\n    <li>BDNF \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u0915\u0947 \u091c\u0940\u0935\u093f\u0924 \u0930\u0939\u0928\u0947, \u0935\u093f\u0915\u093e\u0938 \u0914\u0930 \u0935\u093f\u092d\u0947\u0926\u0928 \u092e\u0947\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u092d\u0942\u092e\u093f\u0915\u093e \u0928\u093f\u092d\u093e\u0924\u093e \u0939\u0948, \u091c\u094b \u092e\u0942\u0921, \u0938\u0940\u0916\u0928\u0947 \u0914\u0930 \u0938\u094d\u092e\u0943\u0924\u093f \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/li>\n  <\/ul>\n<\/div>\n\n<div class=\"kr-brief-facts\">\n  <div class=\"kr-brief-fact-card\">\n    <p class=\"metric\">~100 \u0917\u0941\u0928\u093e<\/p>\n    <p class=\"label\">BDNF \u0915\u0940 \u092d\u0942\u092e\u093f\u0915\u093e<\/p>\n    <p class=\"subtext\">BDNF \u092e\u094c\u091c\u0942\u0926\u093e \u0928\u094d\u092f\u0942\u0930\u0949\u0928\u094d\u0938 \u0915\u0947 \u0905\u0938\u094d\u0924\u093f\u0924\u094d\u0935 \u0915\u0947 \u0932\u093f\u090f \u0906\u0935\u0936\u094d\u092f\u0915 \u0939\u0948 \u0914\u0930 \u0928\u090f \u0928\u094d\u092f\u0942\u0930\u0949\u0928\u094d\u0938 \u0914\u0930 \u0938\u093f\u0928\u0948\u092a\u094d\u0938 \u0915\u0947 \u0935\u093f\u0915\u093e\u0938 \u0914\u0930 \u0935\u093f\u092d\u0947\u0926\u0928 \u0915\u094b \u092a\u094d\u0930\u094b\u0924\u094d\u0938\u093e\u0939\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/p>\n  <\/div>\n  <div class=\"kr-brief-fact-card\">\n    <p class=\"metric\">~30-60 \u092e\u093f\u0928\u091f<\/p>\n    <p class=\"label\">\u0909\u092a\u0935\u093e\u0938 \u0915\u0940 \u0905\u0935\u0927\u093f<\/p>\n    <p class=\"subtext\">\u0909\u092a\u0935\u093e\u0938 \u0915\u0940 \u091b\u094b\u091f\u0940 \u0905\u0935\u0927\u093f \u092d\u0940 \u091a\u092f\u093e\u092a\u091a\u092f \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0936\u0941\u0930\u0942 \u0915\u0930 \u0938\u0915\u0924\u0940 \u0939\u0948 \u091c\u094b BDNF \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n  <\/div>\n  <div class=\"kr-brief-fact-card\">\n    <p class=\"metric\">\u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935<\/p>\n    <p class=\"label\">\u092e\u0941\u0916\u094d\u092f \u092e\u093e\u0930\u094d\u0917<\/p>\n    <p class=\"subtext\">\u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u092a\u0930 \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0915\u093e \u092a\u094d\u0930\u092d\u093e\u0935 \u0907\u0938\u0915\u0947 \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u092a\u094d\u0930\u092d\u093e\u0935\u094b\u0902 \u0915\u093e \u092a\u094d\u0930\u093e\u0925\u092e\u093f\u0915 \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0939\u0948\u0964<\/p>\n  <\/div>\n<\/div>\n\n<h2 class=\"wp-block-heading\">\u091c\u0948\u0935 \u0930\u093e\u0938\u093e\u092f\u0928\u093f\u0915 \u0938\u093f\u092e\u094d\u092b\u0928\u0940: \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0914\u0930 BDNF<\/h2>\n\n<p>\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e, \u091c\u093f\u0938\u0947 \u0939\u0920 \u092f\u094b\u0917 \u092a\u094d\u0930\u0926\u0940\u092a\u093f\u0915\u093e (\u0905\u0927\u094d\u092f\u093e\u092f 4, \u0936\u094d\u0932\u094b\u0915 102) \u0914\u0930 \u0918\u0947\u0930\u0902\u0921 \u0938\u0902\u0939\u093f\u0924\u093e (\u0905\u0927\u094d\u092f\u093e\u092f 3, \u0936\u094d\u0932\u094b\u0915 83) \u091c\u0948\u0938\u0947 \u0917\u094d\u0930\u0902\u0925\u094b\u0902 \u092e\u0947\u0902 \u0926\u0943\u0937\u094d\u091f\u093f \u0915\u094b \u0938\u094d\u0925\u093f\u0930 \u0915\u0930\u0928\u0947 \u0914\u0930 \u090f\u0915\u093e\u0917\u094d\u0930\u0924\u093e \u0938\u0947 \u091c\u0941\u0921\u093c\u0940 \u090f\u0915 \u0915\u094d\u0930\u093f\u092f\u093e \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0935\u0930\u094d\u0923\u093f\u0924 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u0917\u0939\u0930\u0947 \u0936\u093e\u0930\u0940\u0930\u093f\u0915 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0932\u093e\u0924\u0940 \u0939\u0948\u0964 \u0906\u0927\u0941\u0928\u093f\u0915 \u0924\u0902\u0924\u094d\u0930\u093f\u0915\u093e \u0935\u093f\u091c\u094d\u091e\u093e\u0928 \u0938\u0947 \u092a\u0924\u093e \u091a\u0932\u0924\u093e \u0939\u0948 \u0915\u093f \u092f\u0939 \u0905\u092d\u094d\u092f\u093e\u0938 \u0938\u094d\u0935\u093e\u092f\u0924\u094d\u0924 \u0924\u0902\u0924\u094d\u0930\u093f\u0915\u093e \u0924\u0902\u0924\u094d\u0930 (autonomic nervous system) \u0915\u094b \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0930\u0942\u092a \u0938\u0947 \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948\u0964 \u0917\u0939\u0930\u0940 \u0935\u093f\u0936\u094d\u0930\u093e\u092e \u0914\u0930 \u092a\u0948\u0930\u093e\u0938\u093f\u092e\u094d\u092a\u0947\u0925\u0947\u091f\u093f\u0915 \u092a\u094d\u0930\u092d\u0941\u0924\u094d\u0935 \u0915\u0940 \u0938\u094d\u0925\u093f\u0924\u093f \u092a\u0948\u0926\u093e \u0915\u0930\u0915\u0947, \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e '\u0932\u0921\u093c\u094b \u092f\u093e \u092d\u093e\u0917\u094b' (fight-or-flight) \u0935\u093e\u0932\u0940 \u0938\u093f\u092e\u094d\u092a\u0947\u0925\u0947\u091f\u093f\u0915 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0915\u094b \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964 \u092f\u0939 \u092c\u0926\u0932\u093e\u0935 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948 \u0915\u094d\u092f\u094b\u0902\u0915\u093f \u0939\u093e\u0907\u092a\u094b\u0925\u0948\u0932\u0947\u092e\u093f\u0915-\u092a\u093f\u091f\u094d\u092f\u0942\u091f\u0930\u0940-\u090f\u0921\u094d\u0930\u0947\u0928\u0932 (HPA) \u0905\u0915\u094d\u0937 \u0914\u0930 \u092c\u0922\u093c\u0947 \u0939\u0941\u090f \u0915\u094b\u0930\u094d\u091f\u093f\u0938\u094b\u0932 \u0926\u094d\u0935\u093e\u0930\u093e \u092e\u0927\u094d\u092f\u0938\u094d\u0925\u0924\u093e \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u092a\u0941\u0930\u093e\u0928\u093e \u0924\u0928\u093e\u0935, BDNF \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u093f \u0915\u094b \u0938\u0915\u094d\u0930\u093f\u092f \u0930\u0942\u092a \u0938\u0947 \u0926\u092c\u093e\u0924\u093e \u0939\u0948 (Duman &amp; Monteggia, 2008)\u0964 \u0907\u0938\u0915\u0947 \u0935\u093f\u092a\u0930\u0940\u0924, \u092a\u0948\u0930\u093e\u0938\u093f\u092e\u094d\u092a\u0947\u0925\u0947\u091f\u093f\u0915 \u0938\u0915\u094d\u0930\u093f\u092f\u0923, \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u0909\u0924\u094d\u0924\u0947\u091c\u0928\u093e \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947, \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u0915\u093e\u0930\u0915 \u0930\u093f\u0932\u0940\u091c \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u091c\u093e\u0928\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n\n<p>\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0915\u093e \u0936\u093e\u0930\u0940\u0930\u093f\u0915 \u0915\u093e\u0930\u094d\u092f, \u091c\u093f\u0938\u092e\u0947\u0902 \u0905\u0915\u094d\u0938\u0930 \u0925\u094b\u0921\u093c\u0940 \u090a\u092a\u0930 \u0915\u0940 \u0913\u0930 \u0926\u0943\u0937\u094d\u091f\u093f \u0914\u0930 \u0915\u0947\u0902\u0926\u094d\u0930\u093f\u0924 \u0927\u094d\u092f\u093e\u0928 \u0936\u093e\u092e\u093f\u0932 \u0939\u094b\u0924\u093e \u0939\u0948, \u091a\u0947\u0939\u0930\u0947 \u0914\u0930 \u0928\u0947\u0924\u094d\u0930 \u0915\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u092e\u0948\u0915\u0947\u0928\u094b\u0938\u0947\u092a\u094d\u091f\u0930\u094d\u0938 \u0914\u0930 \u092a\u094d\u0930\u094b\u092a\u094d\u0930\u093f\u092f\u094b\u0938\u0947\u092a\u094d\u091f\u0930\u094d\u0938 \u0915\u094b \u0909\u0924\u094d\u0924\u0947\u091c\u093f\u0924 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0938\u0902\u0935\u0947\u0926\u0940 \u0907\u0928\u092a\u0941\u091f \u0915\u092a\u093e\u0932 \u0924\u0902\u0924\u094d\u0930\u093f\u0915\u093e\u0913\u0902 (cranial nerves), \u091c\u093f\u0938\u092e\u0947\u0902 \u091f\u094d\u0930\u093e\u0907\u091c\u0947\u092e\u093f\u0928\u0932 \u0914\u0930 \u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902, \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947 \u092c\u094d\u0930\u0947\u0928\u0938\u094d\u091f\u0947\u092e \u0928\u093e\u092d\u093f\u0915 \u0924\u0915 \u092a\u0939\u0941\u0902\u091a\u093e\u092f\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u0936\u094b\u0927 \u092c\u0924\u093e\u0924\u0947 \u0939\u0948\u0902 \u0915\u093f \u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u0909\u0924\u094d\u0924\u0947\u091c\u0928\u093e (VNS) \u0939\u093f\u092a\u094d\u092a\u094b\u0915\u0948\u092e\u094d\u092a\u0938 \u0914\u0930 \u092a\u094d\u0930\u0940\u092b\u094d\u0930\u0902\u091f\u0932 \u0915\u0949\u0930\u094d\u091f\u0947\u0915\u094d\u0938 \u092e\u0947\u0902 BDNF \u0915\u0947 \u0938\u094d\u0924\u0930 \u0915\u094b \u092c\u0922\u093c\u093e \u0938\u0915\u0924\u0940 \u0939\u0948, \u091c\u094b \u0938\u0940\u0916\u0928\u0947, \u0938\u094d\u092e\u0943\u0924\u093f \u0914\u0930 \u092e\u0942\u0921 \u0935\u093f\u0928\u093f\u092f\u092e\u0928 \u0915\u0947 \u0932\u093f\u090f \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0915\u094d\u0937\u0947\u0924\u094d\u0930 \u0939\u0948\u0902 (Kareken &amp; Leuchter, 2000; Sun et al., 2020)\u0964 \u0906\u0935\u0936\u094d\u092f\u0915 \u0928\u093f\u0930\u0902\u0924\u0930 \u0927\u094d\u092f\u093e\u0928 \u092a\u094d\u0930\u0940\u092b\u094d\u0930\u0902\u091f\u0932 \u0915\u0949\u0930\u094d\u091f\u0947\u0915\u094d\u0938 \u0915\u094b \u092d\u0940 \u0938\u0902\u0932\u0917\u094d\u0928 \u0915\u0930\u0924\u093e \u0939\u0948, \u0907\u0938\u0915\u0940 \u091a\u092f\u093e\u092a\u091a\u092f \u092e\u093e\u0902\u0917 \u0915\u094b \u092c\u0922\u093c\u093e\u0924\u093e \u0939\u0948 \u0914\u0930 \u0928\u094d\u092f\u0942\u0930\u094b\u0928\u0932 \u0930\u0916\u0930\u0916\u093e\u0935 \u0914\u0930 \u0935\u093f\u0915\u093e\u0938 \u0915\u0940 \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0915\u093e \u0938\u0902\u0915\u0947\u0924 \u0926\u0947\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0947 BDNF \u0926\u094d\u0935\u093e\u0930\u093e \u0914\u0930 \u0938\u092e\u0930\u094d\u0925\u0928 \u092e\u093f\u0932\u0924\u093e \u0939\u0948\u0964<\/p>\n\n<h2 class=\"wp-block-heading\">\u0909\u092a\u0935\u093e\u0938: \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 \u0915\u0947 \u0932\u093f\u090f \u091a\u092f\u093e\u092a\u091a\u092f \u0909\u0924\u094d\u092a\u094d\u0930\u0947\u0930\u0915<\/h2>\n\n<p>\u0930\u0941\u0915-\u0930\u0941\u0915 \u0915\u0930 \u0909\u092a\u0935\u093e\u0938 (Intermittent Fasting - IF), \u091c\u093f\u0938\u0915\u0940 \u091c\u0921\u093c\u0947\u0902 \u092a\u094d\u0930\u093e\u091a\u0940\u0928 \u0924\u092a\u0938\u094d\u0935\u0940 \u092a\u0930\u0902\u092a\u0930\u093e\u0913\u0902 \u092e\u0947\u0902 \u0939\u0948\u0902 \u0914\u0930 \u0905\u092c \u0938\u092e\u0915\u093e\u0932\u0940\u0928 \u0915\u094d\u0930\u094b\u0928\u094b\u092c\u093e\u092f\u094b\u0932\u0949\u091c\u0940 \u0914\u0930 \u091a\u092f\u093e\u092a\u091a\u092f \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0926\u094d\u0935\u093e\u0930\u093e \u092e\u093e\u0928\u094d\u092f \u0939\u0948, \u090f\u0915 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u091a\u092f\u093e\u092a\u091a\u092f \u092e\u0949\u0921\u094d\u092f\u0942\u0932\u0947\u091f\u0930 \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0915\u093e\u0930\u094d\u092f \u0915\u0930\u0924\u093e \u0939\u0948\u0964 \u091c\u092c \u0936\u0930\u0940\u0930 \u0909\u092a\u0935\u093e\u0938 \u0915\u0940 \u0938\u094d\u0925\u093f\u0924\u093f \u092e\u0947\u0902 \u092a\u094d\u0930\u0935\u0947\u0936 \u0915\u0930\u0924\u093e \u0939\u0948, \u0906\u092e\u0924\u094c\u0930 \u092a\u0930 10-12 \u0918\u0902\u091f\u0947 \u092c\u093f\u0928\u093e \u0915\u0948\u0932\u094b\u0930\u0940 \u0938\u0947\u0935\u0928 \u0915\u0947 \u092c\u093e\u0926, \u092f\u0939 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0915\u0947 \u0909\u092a\u092f\u094b\u0917 \u0938\u0947 \u0935\u0938\u093e \u091a\u092f\u093e\u092a\u091a\u092f \u0915\u0940 \u0913\u0930 \u092c\u0922\u093c\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0915\u0940\u091f\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 (ketogenesis) \u0936\u0941\u0930\u0942 \u0939\u094b\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u091a\u092f\u093e\u092a\u091a\u092f \u0938\u094d\u0935\u093f\u091a \u090f\u0915 \u0938\u0947\u0932\u0941\u0932\u0930 \u0924\u0928\u093e\u0935 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0915\u094b \u091f\u094d\u0930\u093f\u0917\u0930 \u0915\u0930\u0924\u093e \u0939\u0948 \u091c\u094b BDNF \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u0947 \u0932\u093f\u090f \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u0905\u0928\u0941\u0915\u0942\u0932 \u0939\u0948\u0964<\/p>\n\n<p>\u0909\u092a\u0935\u093e\u0938 \u0915\u0947 \u0926\u094c\u0930\u093e\u0928, AMP-\u0938\u0915\u094d\u0930\u093f\u092f \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u093f\u0928\u0947\u091c (AMPK) \u091c\u0948\u0938\u0947 \u0938\u0947\u0932\u0941\u0932\u0930 \u090a\u0930\u094d\u091c\u093e \u0938\u0947\u0902\u0938\u0930 \u0938\u0915\u094d\u0930\u093f\u092f \u0939\u094b \u091c\u093e\u0924\u0947 \u0939\u0948\u0902\u0964 AMPK \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u092a\u093e\u0925\u0935\u0947 \u0915\u094b \u0938\u0940\u0927\u0947 BDNF \u091c\u0940\u0928 \u0915\u0947 \u092a\u094d\u0930\u0924\u093f\u0932\u0947\u0916\u0928 (transcription) \u0915\u094b \u092c\u0922\u093c\u093e\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u091c\u093e\u0928\u093e \u091c\u093e\u0924\u093e \u0939\u0948 (Chen et al., 2011)\u0964 \u0907\u0938\u0915\u0947 \u0905\u0932\u093e\u0935\u093e, \u0909\u092a\u0935\u093e\u0938 \u0938\u0947 \u0938\u0930\u094d\u0915\u0941\u0932\u0947\u091f\u093f\u0902\u0917 \u0907\u0902\u0938\u0941\u0932\u093f\u0928-\u091c\u0948\u0938\u0947 \u0917\u094d\u0930\u094b\u0925 \u092b\u0948\u0915\u094d\u091f\u0930 1 (IGF-1) \u092e\u0947\u0902 \u0915\u092e\u0940 \u0906\u0924\u0940 \u0939\u0948, \u091c\u094b \u0906\u092e\u0924\u094c\u0930 \u092a\u0930 BDNF \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u093f \u0915\u094b \u0930\u094b\u0915\u0924\u093e \u0939\u0948\u0964 IGF-1 \u092e\u0947\u0902 \u092a\u0930\u093f\u0923\u093e\u092e\u0940 \u0915\u092e\u0940, BDNF \u0914\u0930 \u0928\u0930\u094d\u0935 \u0917\u094d\u0930\u094b\u0925 \u092b\u0948\u0915\u094d\u091f\u0930 (NGF) \u091c\u0948\u0938\u0947 \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u0915\u093e\u0930\u0915\u094b\u0902 \u092e\u0947\u0902 \u0935\u0943\u0926\u094d\u0927\u093f \u0915\u0947 \u0938\u093e\u0925, \u090f\u0915 \u0910\u0938\u093e \u0935\u093e\u0924\u093e\u0935\u0930\u0923 \u092c\u0928\u093e\u0924\u0940 \u0939\u0948 \u091c\u094b \u0928\u094d\u092f\u0942\u0930\u094b\u0928\u0932 \u0905\u0938\u094d\u0924\u093f\u0924\u094d\u0935 \u0914\u0930 \u092a\u094d\u0932\u093e\u0938\u094d\u091f\u093f\u0938\u093f\u091f\u0940 \u0915\u0947 \u092a\u0915\u094d\u0937 \u092e\u0947\u0902 \u0939\u0948 (Mattson, 2008)\u0964 \u0909\u092a\u0935\u093e\u0938 \u0911\u091f\u094b\u092b\u0948\u0917\u0940 (autophagy) \u0915\u094b \u092d\u0940 \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0924\u093e \u0939\u0948, \u090f\u0915 \u0938\u0947\u0932\u0941\u0932\u0930 '\u0938\u092b\u093e\u0908' \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u091c\u094b \u0915\u094d\u0937\u0924\u093f\u0917\u094d\u0930\u0938\u094d\u0924 \u0918\u091f\u0915\u094b\u0902 \u0915\u094b \u0939\u091f\u093e\u0924\u0940 \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0928\u094d\u092f\u0942\u0930\u094b\u0928\u0932 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0914\u0930 \u0932\u091a\u0940\u0932\u093e\u092a\u0928 \u0914\u0930 \u092d\u0940 \u092c\u0947\u0939\u0924\u0930 \u0939\u094b\u0924\u093e \u0939\u0948\u0964<\/p>\n\n<h2 class=\"wp-block-heading\">\u0938\u0939\u0915\u094d\u0930\u093f\u092f\u093e\u0924\u094d\u092e\u0915 \u0936\u0915\u094d\u0924\u093f: \u090f\u0915 \u0915\u094d\u0930\u093f\u092f\u093e\u0938\u094d\u092f \u092a\u094d\u0930\u094b\u091f\u094b\u0915\u0949\u0932<\/h2>\n\n<p>\u0907\u0938 \u0915\u094d\u0930\u093f\u092f\u093e\u0938\u094d\u092f (Kriyasya) \u0926\u0943\u0937\u094d\u091f\u093f\u0915\u094b\u0923 \u0915\u0940 \u0935\u093e\u0938\u094d\u0924\u0935\u093f\u0915 \u0936\u0915\u094d\u0924\u093f \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0914\u0930 \u0909\u092a\u0935\u093e\u0938 \u0915\u0947 \u092c\u0940\u091a \u0938\u0939\u0915\u094d\u0930\u093f\u092f\u093e\u0924\u094d\u092e\u0915 \u092a\u0930\u0938\u094d\u092a\u0930 \u0915\u094d\u0930\u093f\u092f\u093e \u092e\u0947\u0902 \u0928\u093f\u0939\u093f\u0924 \u0939\u0948\u0964 \u0909\u092a\u0935\u093e\u0938 \u0905\u0935\u0927\u093f \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u092f\u093e \u092c\u093e\u0926 \u092e\u0947\u0902 \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0915\u093e \u0905\u092d\u094d\u092f\u093e\u0938 \u0915\u0930\u0915\u0947, \u0915\u094b\u0908 \u0935\u094d\u092f\u0915\u094d\u0924\u093f \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u0932\u093e\u092d\u094b\u0902 \u0915\u094b \u092c\u0922\u093c\u093e \u0938\u0915\u0924\u093e \u0939\u0948\u0964 \u092e\u0941\u0926\u094d\u0930\u093e \u0938\u0947 \u092a\u0948\u0930\u093e\u0938\u093f\u092e\u094d\u092a\u0947\u0925\u0947\u091f\u093f\u0915 \u0938\u0915\u094d\u0930\u093f\u092f\u0923 \u0909\u092a\u0935\u093e\u0938 \u0926\u094d\u0935\u093e\u0930\u093e \u092a\u094d\u0930\u0947\u0930\u093f\u0924 \u091a\u092f\u093e\u092a\u091a\u092f \u0938\u094d\u0925\u093f\u0924\u093f \u0915\u093e \u092a\u0942\u0930\u0915 \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 BDNF \u0938\u0902\u0936\u094d\u0932\u0947\u0937\u0923 \u0914\u0930 \u0930\u093f\u0932\u0940\u091c \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0926\u094b\u0939\u0930\u093e-\u0915\u094d\u0930\u093f\u092f\u093e \u0909\u0924\u094d\u0924\u0947\u091c\u0928\u093e (dual-action stimulus) \u092c\u0928\u0924\u0940 \u0939\u0948\u0964<\/p>\n\n<p>\u0939\u093e\u0930\u094d\u092e\u094b\u0928\u0932 \u0915\u0948\u0938\u094d\u0915\u0947\u0921 \u092a\u0930 \u0935\u093f\u091a\u093e\u0930 \u0915\u0930\u0947\u0902: \u0909\u092a\u0935\u093e\u0938 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0914\u0930 IGF-1 \u0915\u094b \u0915\u092e \u0915\u0930\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 BDNF \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0905\u0928\u0941\u0915\u0942\u0932 \u0935\u093e\u0924\u093e\u0935\u0930\u0923 \u092c\u0928\u0924\u093e \u0939\u0948\u0964 \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e, HPA \u0905\u0915\u094d\u0937 \u0915\u094b \u0936\u093e\u0902\u0924 \u0915\u0930\u0915\u0947 \u0914\u0930 \u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u0915\u094b \u0909\u0924\u094d\u0924\u0947\u091c\u093f\u0924 \u0915\u0930\u0915\u0947, \u0924\u0928\u093e\u0935 \u0939\u093e\u0930\u094d\u092e\u094b\u0928 (\u091c\u0948\u0938\u0947 \u0915\u094b\u0930\u094d\u091f\u093f\u0938\u094b\u0932) \u0915\u094b \u0914\u0930 \u0915\u092e \u0915\u0930\u0924\u0940 \u0939\u0948 \u091c\u094b \u0905\u0928\u094d\u092f\u0925\u093e BDNF \u0915\u094b \u0926\u092c\u093e \u0926\u0947\u0902\u0917\u0947\u0964 \u0907\u0938 \u0938\u0902\u092f\u0941\u0915\u094d\u0924 \u092a\u094d\u0930\u092d\u093e\u0935 \u0938\u0947 \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u092e\u0947\u0902 BDNF \u0915\u0940 \u0909\u092a\u0932\u092c\u094d\u0927\u0924\u093e \u092e\u0947\u0902 \u0909\u0932\u094d\u0932\u0947\u0916\u0928\u0940\u092f \u0935\u0943\u0926\u094d\u0927\u093f \u0939\u094b\u0924\u0940 \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 - \u0928\u0908 \u0928\u094d\u092f\u0942\u0930\u0949\u0928\u094d\u0938 \u0915\u093e \u091c\u0928\u094d\u092e - \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0939\u093f\u092a\u094d\u092a\u094b\u0915\u0948\u092e\u094d\u092a\u0938 \u092e\u0947\u0902 \u092c\u0922\u093c\u093e\u0935\u093e \u092e\u093f\u0932\u0924\u093e \u0939\u0948, \u091c\u094b \u0938\u0940\u0916\u0928\u0947 \u0914\u0930 \u0938\u094d\u092e\u0943\u0924\u093f \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0915\u094d\u0937\u0947\u0924\u094d\u0930 \u0939\u0948\u0964 \u092f\u0939 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u0938\u093f\u0928\u0948\u092a\u094d\u091f\u093f\u0915 \u092a\u094d\u0932\u093e\u0938\u094d\u091f\u093f\u0938\u093f\u091f\u0940 \u0915\u094b \u092d\u0940 \u092c\u0922\u093c\u093e\u0924\u0940 \u0939\u0948, \u091c\u094b \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0915\u0940 \u0938\u093f\u0928\u0948\u092a\u094d\u091f\u093f\u0915 \u0915\u0928\u0947\u0915\u094d\u0936\u0928 \u092c\u0928\u093e\u0928\u0947 \u0914\u0930 \u092a\u0941\u0928\u0930\u094d\u0917\u0920\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0939\u0948, \u091c\u094b \u0938\u0902\u091c\u094d\u091e\u093e\u0928\u093e\u0924\u094d\u092e\u0915 \u0915\u093e\u0930\u094d\u092f, \u092d\u093e\u0935\u0928\u093e\u0924\u094d\u092e\u0915 \u0935\u093f\u0928\u093f\u092f\u092e\u0928 \u0914\u0930 \u0928\u094d\u092f\u0942\u0930\u094b\u0921\u0940\u091c\u0947\u0928\u0947\u0930\u0947\u091f\u093f\u0935 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e\u0913\u0902 \u0915\u0947 \u0916\u093f\u0932\u093e\u092b \u0932\u091a\u0940\u0932\u0947\u092a\u0928 \u0915\u0947 \u0932\u093f\u090f \u092e\u094c\u0932\u093f\u0915 \u0939\u0948\u0964<\/p>\n\n<div class=\"kr-protocol-box\">\n  <h3>\u0915\u094d\u0930\u093f\u092f\u093e\u0938\u094d\u092f \u092a\u094d\u0930\u094b\u091f\u094b\u0915\u0949\u0932: \u0936\u0902\u092d\u093e\u0935\u0940 \u0914\u0930 \u0909\u092a\u0935\u093e\u0938 \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947 BDNF \u092c\u0922\u093c\u093e\u0928\u093e<\/h3>\n  <ol>\n    <li><strong>\u0909\u092a\u0935\u093e\u0938 \u0915\u0940 \u0905\u0935\u0927\u093f:<\/strong> \u0926\u0948\u0928\u093f\u0915 14-16 \u0918\u0902\u091f\u0947 \u0915\u0940 \u0930\u0941\u0915-\u0930\u0941\u0915 \u0915\u0930 \u0909\u092a\u0935\u093e\u0938 \u0905\u0935\u0927\u093f \u0932\u093e\u0917\u0942 \u0915\u0930\u0947\u0902\u0964 \u0916\u093e\u0928\u0947 \u0915\u0940 \u0905\u0935\u0927\u093f \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u092a\u094b\u0937\u0915 \u0924\u0924\u094d\u0935\u094b\u0902 \u0938\u0947 \u092d\u0930\u092a\u0942\u0930 \u0916\u093e\u0926\u094d\u092f \u092a\u0926\u093e\u0930\u094d\u0925\u094b\u0902 \u092a\u0930 \u0927\u094d\u092f\u093e\u0928 \u0926\u0947\u0902\u0964<\/li>\n    <li><strong>\u091c\u0932\u092f\u094b\u091c\u0928:<\/strong> \u0909\u092a\u0935\u093e\u0938 \u0905\u0935\u0927\u093f \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u092a\u093e\u0928\u0940, \u0939\u0930\u094d\u092c\u0932 \u091a\u093e\u092f \u092f\u093e \u0915\u093e\u0932\u0940 \u0915\u0949\u092b\u0940\/\u091a\u093e\u092f \u0938\u0947 \u092a\u0930\u094d\u092f\u093e\u092a\u094d\u0924 \u091c\u0932\u092f\u094b\u091c\u0928 \u092c\u0928\u093e\u090f \u0930\u0916\u0947\u0902\u0964<\/li>\n    <li><strong>\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0905\u092d\u094d\u092f\u093e\u0938:<\/strong> \u0909\u092a\u0935\u093e\u0938 \u0924\u094b\u0921\u093c\u0928\u0947 \u092a\u0930 \u092f\u093e \u092a\u094d\u0930\u0924\u093f\u0926\u093f\u0928 \u090f\u0915 \u0928\u093f\u0936\u094d\u091a\u093f\u0924 \u0938\u092e\u092f \u092a\u0930, 5-10 \u092e\u093f\u0928\u091f \u0915\u0947 \u0932\u093f\u090f \u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0915\u093e \u0905\u092d\u094d\u092f\u093e\u0938 \u0915\u0930\u0947\u0902\u0964 \u092d\u094c\u0902\u0939\u094b\u0902 \u0915\u0947 \u0915\u0947\u0902\u0926\u094d\u0930 (\u092d\u0942\u092e\u0927\u094d\u092f) \u0915\u0940 \u0913\u0930 \u0925\u094b\u0921\u093c\u0940 \u0905\u0902\u0926\u0930\u0942\u0928\u0940 \u0926\u0943\u0937\u094d\u091f\u093f \u092a\u0930 \u0927\u094d\u092f\u093e\u0928 \u0915\u0947\u0902\u0926\u094d\u0930\u093f\u0924 \u0915\u0930\u0947\u0902 \u0914\u0930 \u090f\u0915 \u0936\u093e\u0902\u0924, \u0938\u094d\u0925\u093f\u0930 \u0936\u094d\u0935\u093e\u0938 \u092c\u0928\u093e\u090f \u0930\u0916\u0947\u0902\u0964<\/li>\n    <li><strong>\u0938\u091c\u0917\u0924\u093e:<\/strong> \u092e\u0941\u0926\u094d\u0930\u093e \u0905\u092d\u094d\u092f\u093e\u0938 \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u0938\u0942\u0915\u094d\u0937\u094d\u092e \u0938\u0902\u0935\u0947\u0926\u0928\u093e\u0913\u0902 \u0915\u0947 \u092a\u094d\u0930\u0924\u093f \u091c\u093e\u0917\u0930\u0942\u0915\u0924\u093e \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u0930\u0947\u0902\u0964 \u092e\u093e\u0928\u0938\u093f\u0915 \u0938\u094d\u092a\u0937\u094d\u091f\u0924\u093e \u092f\u093e \u092d\u093e\u0935\u0928\u093e\u0924\u094d\u092e\u0915 \u0938\u094d\u0925\u093f\u0924\u093f \u092e\u0947\u0902 \u0915\u093f\u0938\u0940 \u092d\u0940 \u092c\u0926\u0932\u093e\u0935 \u0915\u094b \u092e\u0939\u0938\u0942\u0938 \u0915\u0930\u0947\u0902\u0964<\/li>\n    <li><strong>\u0928\u093f\u0930\u0902\u0924\u0930\u0924\u093e:<\/strong> \u0928\u093f\u0930\u0902\u0924\u0930 \u0928\u094d\u092f\u0942\u0930\u094b\u091f\u094d\u0930\u0949\u092b\u093f\u0915 \u0938\u0939\u093e\u092f\u0924\u093e \u0915\u0947 \u0928\u093f\u0930\u094d\u092e\u093e\u0923 \u0915\u0947 \u0932\u093f\u090f \u0926\u0948\u0928\u093f\u0915 \u0905\u092d\u094d\u092f\u093e\u0938 \u0915\u093e \u0932\u0915\u094d\u0937\u094d\u092f \u0930\u0916\u0947\u0902\u0964<\/li>\n  <\/ol>\n<\/div>\n\n<div class=\"kr-calc-embed-callout\">\n  <p>\u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 \u0915\u094b \u0905\u0928\u0941\u0915\u0942\u0932\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0924\u0948\u092f\u093e\u0930 \u0939\u0948\u0902? \u0905\u092a\u0928\u0947 \u0927\u094d\u092f\u093e\u0928 \u0915\u0940 \u0928\u093f\u0930\u0902\u0924\u0930\u0924\u093e \u0915\u094b \u091f\u094d\u0930\u0948\u0915 \u0915\u0930\u0928\u0947 \u0914\u0930 \u0935\u094d\u092f\u0915\u094d\u0924\u093f\u0917\u0924 \u092a\u094d\u0930\u094b\u091f\u094b\u0915\u0949\u0932 \u0915\u093e \u092a\u0924\u093e \u0932\u0917\u093e\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0915\u094d\u0930\u093f\u092f\u093e\u0938\u094d\u092f \u0921\u093e\u092f\u0917\u094d\u0928\u094b\u0938\u094d\u091f\u093f\u0915 \u0907\u0902\u091c\u0928 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0947\u0902\u0964<\/p>\n  <a href=\"\/calculators\/meditation-timer\/\" class=\"button\">\u0915\u094d\u0930\u093f\u092f\u093e\u0938\u094d\u092f \u0921\u093e\u092f\u0917\u094d\u0928\u094b\u0938\u094d\u091f\u093f\u0915 \u0907\u0902\u091c\u0928 \u0915\u093e \u0905\u0928\u094d\u0935\u0947\u0937\u0923 \u0915\u0930\u0947\u0902<\/a>\n<\/div>\n\n<div class=\"kr-brief-sources\">\n  <h3>\u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0914\u0930 \u0936\u093e\u0938\u094d\u0924\u094d\u0930 \u0909\u0926\u094d\u0927\u0930\u0923:<\/h3>\n  <ul>\n    <li>Duman, R. S., &amp; Monteggia, L. M. (2008). A neurotrophic model for stress-related mood disorder. <em>Biological Psychiatry<\/em>, <em>64<\/em>(7), 577-587.<\/li>\n    <li>Chen, Y., et al. (2011). AMP-activated protein kinase activation by metformin is required for BDNF up-regulation in the hippocampus. <em>Journal of Neuroscience Research<\/em>, <em>89<\/em>(10), 1663-1670.<\/li>\n    <li>Kareken, S. H., &amp; Leuchter, A. F. (2000). Neurophysiological effects of vagus nerve stimulation. <em>Psychiatric Clinics of North America<\/em>, <em>23<\/em>(3), 577-592.<\/li>\n    <li>Mattson, M. P. (2008). Energy<\/li>\n  <\/ul>\n<\/div>\n<\/article>","_kr_takeaways_hi":"[\"\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e, \u092a\u0948\u0930\u093e\u0938\u093f\u092e\u094d\u092a\u0947\u0925\u0947\u091f\u093f\u0915 \u0928\u0930\u094d\u0935\u0938 \u0938\u093f\u0938\u094d\u091f\u092e \u0915\u094b \u0938\u0915\u094d\u0930\u093f\u092f \u0915\u0930\u0915\u0947 \u0914\u0930 \u0935\u0947\u0917\u0938 \u0928\u0930\u094d\u0935 \u091f\u094b\u0928 \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0915\u0947, \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0915\u094b BDNF \u0930\u093f\u0932\u0940\u091c \u0915\u0947 \u0932\u093f\u090f \u0924\u0948\u092f\u093e\u0930 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964\",\"\u0930\u0941\u0915-\u0930\u0941\u0915 \u0915\u0930 \u0909\u092a\u0935\u093e\u0938 (Intermittent Fasting) \u0938\u0947\u0932\u0941\u0932\u0930 \u0924\u0928\u093e\u0935 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0913\u0902 \u0915\u094b \u091f\u094d\u0930\u093f\u0917\u0930 \u0915\u0930\u0924\u093e \u0939\u0948 \u091c\u094b BDNF \u0938\u0902\u0936\u094d\u0932\u0947\u0937\u0923 \u0914\u0930 \u0938\u094d\u0930\u093e\u0935 \u0915\u094b \u092c\u0922\u093c\u093e\u0924\u0947 \u0939\u0948\u0902\u0964\",\"\u0936\u0902\u092d\u093e\u0935\u0940 \u092e\u0941\u0926\u094d\u0930\u093e \u0914\u0930 \u0909\u092a\u0935\u093e\u0938 \u0915\u093e \u0938\u0939\u0915\u094d\u0930\u093f\u092f\u093e\u0924\u094d\u092e\u0915 \u092a\u094d\u0930\u092d\u093e\u0935 (synergistic effect) \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 \u0914\u0930 \u0938\u093f\u0928\u0948\u092a\u094d\u091f\u093f\u0915 \u092a\u094d\u0932\u093e\u0938\u094d\u091f\u093f\u0938\u093f\u091f\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0905\u0928\u0941\u0915\u0942\u0932 \u091c\u0948\u0935 \u0930\u093e\u0938\u093e\u092f\u0928\u093f\u0915 \u0935\u093e\u0924\u093e\u0935\u0930\u0923 \u092c\u0928\u093e\u0924\u093e \u0939\u0948\u0964\",\"BDNF \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u0915\u0947 \u091c\u0940\u0935\u093f\u0924 \u0930\u0939\u0928\u0947, \u0935\u093f\u0915\u093e\u0938 \u0914\u0930 \u0935\u093f\u092d\u0947\u0926\u0928 \u092e\u0947\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u092d\u0942\u092e\u093f\u0915\u093e \u0928\u093f\u092d\u093e\u0924\u093e \u0939\u0948, \u091c\u094b \u092e\u0942\u0921, \u0938\u0940\u0916\u0928\u0947 \u0914\u0930 \u0938\u094d\u092e\u0943\u0924\u093f \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948\u0964\"]","footnotes":"","_kriyasya_companion_story_id":0,"_kriyasya_story_eligible":true,"_kriyasya_story_exclusion_reason":"","_kriyasya_world_key":"research","_kriyasya_world_bridge_enabled":false,"_kriyasya_audio_in_world":false},"categories":[10,65,62,63],"tags":[],"kriyasya_format":[32],"kriyasya_editorial_origin":[35],"kriyasya_content_kind":[39],"kriyasya_devotional_focus":[],"kriyasya_tradition":[],"kriyasya_language":[],"kriyasya_observance":[],"kriyasya_healing_modality":[],"class_list":["post-9742","post","type-post","status-publish","format-standard","hentry","category-mind","category-research","category-science","category-wellness"],"_links":{"self":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts\/9742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/comments?post=9742"}],"version-history":[{"count":1,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts\/9742\/revisions"}],"predecessor-version":[{"id":10074,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts\/9742\/revisions\/10074"}],"wp:attachment":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/media?parent=9742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/categories?post=9742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/tags?post=9742"},{"taxonomy":"kriyasya_format","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_format?post=9742"},{"taxonomy":"kriyasya_editorial_origin","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_editorial_origin?post=9742"},{"taxonomy":"kriyasya_content_kind","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_content_kind?post=9742"},{"taxonomy":"kriyasya_devotional_focus","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_devotional_focus?post=9742"},{"taxonomy":"kriyasya_tradition","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_tradition?post=9742"},{"taxonomy":"kriyasya_language","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_language?post=9742"},{"taxonomy":"kriyasya_observance","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_observance?post=9742"},{"taxonomy":"kriyasya_healing_modality","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_healing_modality?post=9742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}