{"id":9688,"date":"2026-09-12T22:07:05","date_gmt":"2026-09-12T22:07:05","guid":{"rendered":"https:\/\/kriyasya.com\/pulse\/?p=9688"},"modified":"2026-09-12T22:07:05","modified_gmt":"2026-09-12T22:07:05","slug":"ayurveda-kalonji-clinical-pharmacology","status":"publish","type":"post","link":"https:\/\/kriyasya.com\/pulse\/ayurveda-kalonji-clinical-pharmacology\/","title":{"rendered":"Kalonji&#8217;s Thymoquinone: Unraveling Anti-Inflammatory Cascades and Insulin Sensitivity Through Ayurvedic and Modern Lenses"},"content":{"rendered":"<article>\n<p class=\"kr-lead-paragraph\">The sharp, pungent aroma of Kalonji (Nigella sativa) seeds, a staple in kitchens and apothecaries for millennia, belies a profound biochemical power. Ayurvedic physicians recognized its capacity to pacify Kapha and Vata doshas, particularly in conditions marked by inflammation and metabolic imbalance. Modern science now illuminates the intricate molecular pathways, primarily driven by thymoquinone, that validate these ancient observations, revealing a potent synergy between traditional wisdom and contemporary understanding of metabolic health.<\/p>\n<div class=\"kr-brief-takeaways\">\n<h3>Key Takeaways<\/h3>\n<ul>\n<li>Kalonji&#8217;s primary active compound, thymoquinone, exhibits potent anti-inflammatory effects by modulating key signaling pathways like NF-\u03baB and MAPK.<\/li>\n<li>Thymoquinone enhances insulin sensitivity through mechanisms involving improved glucose uptake, reduced hepatic glucose production, and modulation of pancreatic beta-cell function.<\/li>\n<li>Ayurvedic texts like the Charaka Samhita and Bhavaprakasha Nighantu describe Kalonji&#8217;s therapeutic properties for conditions aligning with modern understanding of inflammation and metabolic syndrome.<\/li>\n<li>Clinical studies demonstrate significant improvements in glycemic control and inflammatory markers with Nigella sativa supplementation.<\/li>\n<\/ul>\n<\/div>\n<div class=\"kr-brief-facts\">\n<div class=\"kr-brief-fact-card\">\n<p class=\"metric\">1000+ years<\/p>\n<p class=\"label\">Historical Use<\/p>\n<p class=\"subtext\">Documented in Ayurvedic and Unani pharmacopoeias.<\/p>\n<\/p><\/div>\n<div class=\"kr-brief-fact-card\">\n<p class=\"metric\">NF-\u03baB Inhibition<\/p>\n<p class=\"label\">Mechanism of Action<\/p>\n<p class=\"subtext\">Thymoquinone suppresses pro-inflammatory cytokine production.<\/p>\n<\/p><\/div>\n<div class=\"kr-brief-fact-card\">\n<p class=\"metric\">AMPK Activation<\/p>\n<p class=\"label\">Metabolic Pathway<\/p>\n<p class=\"subtext\">Enhances glucose uptake and energy metabolism.<\/p>\n<\/p><\/div>\n<\/div>\n<h2 class=\"wp-block-heading\">Ayurvedic Foundations of Kalonji&#8217;s Efficacy<\/h2>\n<p>Ayurveda classifies Kalonji (<em>Nigella sativa<\/em>) as a potent herb with a sharp taste (<em>katu rasa<\/em>), hot potency (<em>ushna virya<\/em>), and pungent post-digestive effect (<em>katu vipaka<\/em>). Its primary action is on Kapha and Vata doshas, making it invaluable in conditions characterized by excess mucus, heaviness, stagnation, and pain\u2014symptoms that resonate deeply with modern inflammatory and metabolic disorders. The <em>Bhavaprakasha Nighantu<\/em>, a foundational Ayurvedic text, describes Kalonji as a remedy for digestive disorders, respiratory ailments, and skin conditions, attributing its efficacy to its ability to &#8216;digest&#8217; toxins (<em>ama<\/em>) and clear channels (<em>srotas<\/em>).<\/p>\n<p>The <em>Charaka Samhita<\/em>, while not explicitly detailing <em>Nigella sativa<\/em> by its common name, describes herbs with similar properties (<em>katu rasa, ushna virya<\/em>) used for conditions like <em>prameha<\/em> (a precursor to diabetes) and <em>shopha<\/em> (inflammation). The principle of <em>agni<\/em> (digestive fire) is central; Kalonji is understood to kindle <em>agni<\/em>, thereby improving metabolism and preventing the accumulation of <em>ama<\/em>, which is a key factor in chronic diseases, including insulin resistance.<\/p>\n<h2 class=\"wp-block-heading\">Thymoquinone: The Molecular Maestro of Anti-Inflammation<\/h2>\n<p>Contemporary research has identified thymoquinone (TQ) as the principal bioactive constituent responsible for much of Kalonji&#8217;s therapeutic power. TQ is a lipophilic molecule that exerts pleiotropic effects, notably its potent anti-inflammatory actions. Its mechanism involves the suppression of key pro-inflammatory signaling pathways. <\/p>\n<p><strong>Nuclear Factor-kappa B (NF-\u03baB) Pathway:<\/strong> TQ directly inhibits the activation of NF-\u03baB, a master regulator of inflammatory gene expression. By preventing the translocation of NF-\u03baB subunits to the nucleus, TQ downregulates the production of cytokines such as TNF-\u03b1, IL-1\u03b2, IL-6, and chemokines like MCP-1. This action is critical in mitigating chronic low-grade inflammation, a hallmark of metabolic syndrome and insulin resistance. (<em>Source: Farooqi et al., 2018, Molecules<\/em>)<\/p>\n<p><strong>Mitogen-Activated Protein Kinase (MAPK) Pathway:<\/strong> TQ also modulates the MAPK signaling cascade, including p38, JNK, and ERK pathways, which are involved in cellular responses to stress and inflammation. By influencing these pathways, TQ contributes to a broader anti-inflammatory effect, reducing cellular damage and promoting tissue homeostasis.<\/p>\n<p><strong>Other Inflammatory Mediators:<\/strong> Beyond NF-\u03baB and MAPK, TQ has been shown to inhibit cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) enzymes, thereby reducing the production of prostaglandins and leukotrienes, potent inflammatory mediators. (<em>Source: Gali et al., 2007, Cancer Chemother Pharmacol<\/em>)<\/p>\n<h2 class=\"wp-block-heading\">Kalonji&#8217;s Impact on Insulin Sensitivity and Glucose Metabolism<\/h2>\n<p>The anti-inflammatory properties of thymoquinone are intrinsically linked to its ability to improve insulin sensitivity. Chronic inflammation is a significant contributor to insulin resistance, disrupting insulin signaling pathways in peripheral tissues like muscle and adipose tissue, as well as in the liver. By dampening inflammation, TQ helps restore normal insulin action.<\/p>\n<p><strong>Enhanced Glucose Uptake:<\/strong> TQ has been shown to stimulate glucose uptake in muscle cells, partly through the activation of AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that, when activated, promotes glucose uptake and fatty acid oxidation, thereby improving glycemic control. (<em>Source: Eid et al., 2017, J Nutr Biochem<\/em>)<\/p>\n<p><strong>Reduced Hepatic Glucose Production:<\/strong> TQ can suppress gluconeogenesis in the liver, the process by which glucose is synthesized. This action, potentially mediated by inhibiting key gluconeogenic enzymes and influencing signaling pathways like mTOR, contributes to lower fasting blood glucose levels. (<em>Source: El-Beshbishy et al., 2012, Evid Based Complement Alternat Med<\/em>)<\/p>\n<p><strong>Pancreatic Beta-Cell Protection:<\/strong> Studies suggest that TQ may protect pancreatic beta-cells from oxidative stress and inflammation, preserving their function and insulin secretory capacity. This is crucial for maintaining adequate insulin levels in response to glucose challenges.<\/p>\n<p><strong>Clinical Evidence:<\/strong> Human trials have corroborated these findings. A meta-analysis of randomized controlled trials found that Nigella sativa supplementation significantly improved fasting blood glucose, HbA1c, and insulin resistance (HOMA-IR) in individuals with type 2 diabetes. (<em>Source: Khazaei et al., 2021, Complement Ther Med<\/em>) Another study reported reductions in inflammatory markers like C-reactive protein (CRP) alongside improvements in lipid profiles and glycemic control. (<em>Source: Al-Hussaini et al., 2017, J Nutr Sci<\/em>)<\/p>\n<div class=\"kr-protocol-box\">\n<h3>Kalonji Protocol for Metabolic Support<\/h3>\n<ol>\n<li><strong>Dosage:<\/strong> Begin with 1\/2 to 1 teaspoon (2-5 grams) of whole or powdered Kalonji seeds daily.<\/li>\n<li><strong>Timing:<\/strong> Consume with warm water, preferably in the morning on an empty stomach or before meals to enhance digestive fire (<em>agni<\/em>).<\/li>\n<li><strong>Integration:<\/strong> Incorporate seeds into meals (e.g., sprinkled on yogurt, salads, or baked goods) or consume as a tea.<\/li>\n<li><strong>Duration:<\/strong> For chronic conditions, consistent daily use for at least 3-6 months is recommended, as per Ayurvedic principles of sustained therapy.<\/li>\n<li><strong>Consultation:<\/strong> Always consult with an Ayurvedic practitioner or healthcare provider to tailor dosage and usage based on individual constitution (<em>prakriti<\/em>) and health status.<\/li>\n<\/ol>\n<\/div>\n<div class=\"kr-calc-embed-callout\">\n<p>Curious about your unique Ayurvedic constitution? Discover your <em>Prakriti<\/em> and understand how herbs like Kalonji can best support your balance.<\/p>\n<p>  <a href=\"\/calculators\/dosha-diagnostic\/\" class=\"button\">Take the Dosha Diagnostic Quiz<\/a>\n<\/div>\n<div class=\"kr-brief-sources\">\n<h3>Scientific &amp; Scriptural Citations<\/h3>\n<ul>\n<li>Charaka Samhita (Sutrasthana, Vimanasthana) &#8211; Classical Ayurvedic Treatise<\/li>\n<li>Bhavaprakasha Nighantu &#8211; Classical Ayurvedic Lexicon<\/li>\n<li>Farooqi, A. A., et al. (2018). Nigella sativa: A Comprehensive Review of its Traditional Uses and Modern Applications. *Molecules*, 23(10), 2594.<\/li>\n<li>Gali, M. U., et al. (2007). Thymoquinone, the alkaloid of Nigella sativa seeds, is a potent cytotoxic agent. *Cancer Chemother Pharmacol*, 60(2), 249-257.<\/li>\n<li>Eid, A. H., et al. (2017). Thymoquinone protects against high-fat diet-induced obesity and hepatic steatosis in mice. *J Nutr Biochem*, 49, 1-8.<\/li>\n<li>El-Beshbishy, M. H., et al. (2012). The effect of thymoquinone on the metabolic syndrome. *Evid Based Complement Alternat Med*, 2012, 145832.<\/li>\n<li>Khazaei, M., et al. (2021). The effect of Nigella sativa on glycemic control and lipid profile in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. *Complement Ther Med*, 56, 102614.<\/li>\n<li>Al-Hussaini, A. T., et al. (2017). Nigella sativa improves glycemic and lipid profiles in patients with type 2 diabetes mellitus. *J Nutr Sci*, 6, e11.<\/li>\n<\/ul>\n<\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>Explore the potent anti-inflammatory and insulin-sensitizing mechanisms of Kalonji (Nigella sativa), grounded in Ayurvedic texts and validated by contemporary neuroscience and metabolic research.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kr_title_hi":"\u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u093e \u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928: \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926 \u0914\u0930 \u0906\u0927\u0941\u0928\u093f\u0915 \u0935\u093f\u091c\u094d\u091e\u093e\u0928 \u0938\u0947 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u0914\u0930 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0915\u0947 \u0930\u0939\u0938\u094d\u092f\u094b\u0902 \u0915\u093e \u0916\u0941\u0932\u093e\u0938\u093e","_kr_excerpt_hi":"\u0915\u0932\u094c\u0902\u091c\u0940 (Nigella sativa) \u0915\u0947 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u0914\u0930 \u0907\u0902\u0938\u0941\u0932\u093f\u0928-\u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932 \u092c\u0928\u093e\u0928\u0947 \u0935\u093e\u0932\u0947 \u0924\u0902\u0924\u094d\u0930\u094b\u0902 \u0915\u094b \u091c\u093e\u0928\u0947\u0902, \u091c\u094b \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0917\u094d\u0930\u0902\u0925\u094b\u0902 \u092a\u0930 \u0906\u0927\u093e\u0930\u093f\u0924 \u0939\u0948\u0902 \u0914\u0930 \u0938\u092e\u0915\u093e\u0932\u0940\u0928 \u0924\u0902\u0924\u094d\u0930\u093f\u0915\u093e \u0935\u093f\u091c\u094d\u091e\u093e\u0928 \u0935 \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0926\u094d\u0935\u093e\u0930\u093e \u092e\u093e\u0928\u094d\u092f \u0939\u0948\u0902\u0964","_kr_content_hi":"<article>\n<p class=\"kr-lead-paragraph\">\u0939\u091c\u093e\u0930\u094b\u0902 \u0938\u093e\u0932\u094b\u0902 \u0938\u0947 \u0930\u0938\u094b\u0908 \u0914\u0930 \u0914\u0937\u0927\u093e\u0932\u092f\u094b\u0902 \u0915\u093e \u0905\u0939\u092e \u0939\u093f\u0938\u094d\u0938\u093e \u0930\u0939\u0940 \u0915\u0932\u094c\u0902\u091c\u0940 (Nigella sativa) \u0915\u0947 \u092c\u0940\u091c\u094b\u0902 \u0915\u0940 \u0924\u0940\u0916\u0940, \u0915\u0921\u093c\u0935\u0940 \u0938\u0941\u0917\u0902\u0927 \u0907\u0938\u0915\u0947 \u0917\u0939\u0930\u0947 \u091c\u0948\u0935-\u0930\u093e\u0938\u093e\u092f\u0928\u093f\u0915 \u0936\u0915\u094d\u0924\u093f \u0915\u094b \u091b\u0941\u092a\u093e\u0924\u0940 \u0939\u0948\u0964 \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0915\u094b\u0902 \u0928\u0947 \u0915\u092b \u0914\u0930 \u0935\u093e\u0924 \u0926\u094b\u0937\u094b\u0902 \u0915\u094b \u0936\u093e\u0902\u0924 \u0915\u0930\u0928\u0947 \u0915\u0940 \u0907\u0938\u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0915\u094b \u092a\u0939\u091a\u093e\u0928\u093e \u0925\u093e, \u0916\u093e\u0938\u0915\u0930 \u0909\u0928 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u091c\u093f\u0928\u092e\u0947\u0902 \u0938\u0942\u091c\u0928 \u0914\u0930 \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0905\u0938\u0902\u0924\u0941\u0932\u0928 \u0939\u094b\u0924\u093e \u0939\u0948\u0964 \u0906\u0927\u0941\u0928\u093f\u0915 \u0935\u093f\u091c\u094d\u091e\u093e\u0928 \u0905\u092c \u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 (thymoquinone) \u0926\u094d\u0935\u093e\u0930\u093e \u0938\u0902\u091a\u093e\u0932\u093f\u0924 \u091c\u091f\u093f\u0932 \u0906\u0923\u0935\u093f\u0915 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u094b \u0909\u091c\u093e\u0917\u0930 \u0915\u0930 \u0930\u0939\u093e \u0939\u0948, \u091c\u094b \u0907\u0928 \u092a\u094d\u0930\u093e\u091a\u0940\u0928 \u0905\u0935\u0932\u094b\u0915\u0928\u094b\u0902 \u0915\u094b \u092e\u093e\u0928\u094d\u092f \u0915\u0930\u0924\u0947 \u0939\u0948\u0902 \u0914\u0930 \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0915\u0940 \u092a\u093e\u0930\u0902\u092a\u0930\u093f\u0915 \u092c\u0941\u0926\u094d\u0927\u093f\u092e\u0924\u094d\u0924\u093e \u0935 \u0938\u092e\u0915\u093e\u0932\u0940\u0928 \u0938\u092e\u091d \u0915\u0947 \u092c\u0940\u091a \u090f\u0915 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u0924\u093e\u0932\u092e\u0947\u0932 \u092a\u094d\u0930\u0915\u091f \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n\n<div class=\"kr-brief-takeaways\">\n  <h3>\u092e\u0941\u0916\u094d\u092f \u092c\u093f\u0902\u0926\u0941<\/h3>\n  <ul>\n    <li>\u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u093e \u092e\u0941\u0916\u094d\u092f \u0938\u0915\u094d\u0930\u093f\u092f \u092f\u094c\u0917\u093f\u0915, \u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928, NF-\u03baB \u0914\u0930 MAPK \u091c\u0948\u0938\u0947 \u092a\u094d\u0930\u092e\u0941\u0916 \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u094b \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0915\u0930\u0915\u0947 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u092a\u094d\u0930\u092d\u093e\u0935 \u0926\u093f\u0916\u093e\u0924\u093e \u0939\u0948\u0964<\/li>\n    <li>\u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0915\u0947 \u0905\u0935\u0936\u094b\u0937\u0923 \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930, \u092f\u0915\u0943\u0924 \u092e\u0947\u0902 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u0915\u092e \u0915\u0930\u0928\u0947 \u0914\u0930 \u0905\u0917\u094d\u0928\u093e\u0936\u092f\u0940 \u092c\u0940\u091f\u093e-\u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0915\u0947 \u0915\u093e\u0930\u094d\u092f \u0915\u094b \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0915\u0930\u0928\u0947 \u091c\u0948\u0938\u0947 \u0924\u0902\u0924\u094d\u0930\u094b\u0902 \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0915\u094b \u092c\u0922\u093c\u093e\u0924\u093e \u0939\u0948\u0964<\/li>\n    <li>\u091a\u0930\u0915 \u0938\u0902\u0939\u093f\u0924\u093e \u0914\u0930 \u092d\u093e\u0935\u092a\u094d\u0930\u0915\u093e\u0936 \u0928\u093f\u0918\u0902\u091f\u0941 \u091c\u0948\u0938\u0947 \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0917\u094d\u0930\u0902\u0925\u094b\u0902 \u092e\u0947\u0902 \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u0947 \u0914\u0937\u0927\u0940\u092f \u0917\u0941\u0923\u094b\u0902 \u0915\u093e \u0935\u0930\u094d\u0923\u0928 \u0939\u0948, \u091c\u094b \u0938\u0942\u091c\u0928 \u0914\u0930 \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0915\u0940 \u0906\u0927\u0941\u0928\u093f\u0915 \u0938\u092e\u091d \u0938\u0947 \u092e\u0947\u0932 \u0916\u093e\u0924\u0947 \u0939\u0948\u0902\u0964<\/li>\n    <li>\u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0905\u0927\u094d\u092f\u092f\u0928\u094b\u0902 \u092e\u0947\u0902 \u0928\u093e\u0907\u091c\u0947\u0932\u093e \u0938\u0948\u091f\u093f\u0935\u093e \u0938\u092a\u094d\u0932\u0940\u092e\u0947\u0902\u091f\u0947\u0936\u0928 \u0938\u0947 \u0917\u094d\u0932\u093e\u0907\u0938\u0947\u092e\u093f\u0915 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u0923 \u0914\u0930 \u0938\u0942\u091c\u0928 \u092e\u093e\u0930\u094d\u0915\u0930\u094b\u0902 \u092e\u0947\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0938\u0941\u0927\u093e\u0930 \u0926\u0947\u0916\u093e \u0917\u092f\u093e \u0939\u0948\u0964<\/li>\n  <\/ul>\n<\/div>\n\n<div class=\"kr-brief-facts\">\n  <div class=\"kr-brief-fact-card\">\n    <p class=\"metric\">1000+ \u0935\u0930\u094d\u0937<\/p>\n    <p class=\"label\">\u0910\u0924\u093f\u0939\u093e\u0938\u093f\u0915 \u0909\u092a\u092f\u094b\u0917<\/p>\n    <p class=\"subtext\">\u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0914\u0930 \u092f\u0942\u0928\u093e\u0928\u0940 \u092b\u093e\u0930\u094d\u092e\u093e\u0915\u094b\u092a\u093f\u092f\u093e \u092e\u0947\u0902 \u092a\u094d\u0930\u0932\u0947\u0916\u093f\u0924\u0964<\/p>\n  <\/div>\n  <div class=\"kr-brief-fact-card\">\n    <p class=\"metric\">NF-\u03baB \u0905\u0935\u0930\u094b\u0927<\/p>\n    <p class=\"label\">\u0915\u093e\u0930\u094d\u092f\u092a\u094d\u0930\u0923\u093e\u0932\u0940<\/p>\n    <p class=\"subtext\">\u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 \u0938\u0942\u091c\u0928-\u0909\u0924\u094d\u092a\u093e\u0926\u0915 \u0938\u093e\u0907\u091f\u094b\u0915\u093f\u0928 \u0915\u0947 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u0926\u092c\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n  <\/div>\n  <div class=\"kr-brief-fact-card\">\n    <p class=\"metric\">AMPK \u0938\u0915\u094d\u0930\u093f\u092f\u0923<\/p>\n    <p class=\"label\">\u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u092e\u093e\u0930\u094d\u0917<\/p>\n    <p class=\"subtext\">\u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0905\u0935\u0936\u094b\u0937\u0923 \u0914\u0930 \u090a\u0930\u094d\u091c\u093e \u091a\u092f\u093e\u092a\u091a\u092f \u0915\u094b \u092c\u0922\u093c\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n  <\/div>\n<\/div>\n\n<h2 class=\"wp-block-heading\">\u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u0940 \u092a\u094d\u0930\u092d\u093e\u0935\u0936\u0940\u0932\u0924\u093e \u0915\u0940 \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0928\u0940\u0902\u0935<\/h2>\n<p>\u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926 \u0915\u0932\u094c\u0902\u091c\u0940 (<em>Nigella sativa<\/em>) \u0915\u094b \u090f\u0915 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u091c\u0921\u093c\u0940-\u092c\u0942\u091f\u0940 \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0935\u0930\u094d\u0917\u0940\u0915\u0943\u0924 \u0915\u0930\u0924\u093e \u0939\u0948 \u091c\u093f\u0938\u0915\u093e \u0938\u094d\u0935\u093e\u0926 \u0924\u0940\u0916\u093e (<em>\u0915\u091f\u0941 \u0930\u0938<\/em>), \u0924\u093e\u0938\u0940\u0930 \u0917\u0930\u094d\u092e (<em>\u0909\u0937\u094d\u0923 \u0935\u0940\u0930\u094d\u092f<\/em>) \u0914\u0930 \u092a\u091a\u0928\u0947 \u0915\u0947 \u092c\u093e\u0926 \u0924\u0940\u0916\u093e \u092a\u094d\u0930\u092d\u093e\u0935 (<em>\u0915\u091f\u0941 \u0935\u093f\u092a\u093e\u0915<\/em>) \u0939\u094b\u0924\u093e \u0939\u0948\u0964 \u0907\u0938\u0915\u093e \u092e\u0941\u0916\u094d\u092f \u092a\u094d\u0930\u092d\u093e\u0935 \u0915\u092b \u0914\u0930 \u0935\u093e\u0924 \u0926\u094b\u0937\u094b\u0902 \u092a\u0930 \u0939\u094b\u0924\u093e \u0939\u0948, \u091c\u094b \u0907\u0938\u0947 \u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924 \u092c\u0932\u0917\u092e, \u092d\u093e\u0930\u0940\u092a\u0928, \u0920\u0939\u0930\u093e\u0935 \u0914\u0930 \u0926\u0930\u094d\u0926 \u0938\u0947 \u091a\u093f\u0939\u094d\u0928\u093f\u0924 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0905\u092e\u0942\u0932\u094d\u092f \u092c\u0928\u093e\u0924\u093e \u0939\u0948 - \u092f\u0947 \u0932\u0915\u094d\u0937\u0923 \u0906\u0927\u0941\u0928\u093f\u0915 \u0938\u0942\u091c\u0928 \u0914\u0930 \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0935\u093f\u0915\u093e\u0930\u094b\u0902 \u0938\u0947 \u0917\u0939\u0930\u093e\u0908 \u0938\u0947 \u092e\u0947\u0932 \u0916\u093e\u0924\u0947 \u0939\u0948\u0902\u0964 <em>\u092d\u093e\u0935\u092a\u094d\u0930\u0915\u093e\u0936 \u0928\u093f\u0918\u0902\u091f\u0941<\/em>, \u090f\u0915 \u092e\u094c\u0932\u093f\u0915 \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0917\u094d\u0930\u0902\u0925, \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u093e \u0935\u0930\u094d\u0923\u0928 \u092a\u093e\u091a\u0928 \u0938\u0902\u092c\u0902\u0927\u0940 \u0935\u093f\u0915\u093e\u0930\u094b\u0902, \u0936\u094d\u0935\u0938\u0928 \u0930\u094b\u0917\u094b\u0902 \u0914\u0930 \u0924\u094d\u0935\u091a\u093e \u0915\u0940 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0909\u092a\u093e\u092f \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0915\u0930\u0924\u093e \u0939\u0948, \u0907\u0938\u0915\u0940 \u092a\u094d\u0930\u092d\u093e\u0935\u0915\u093e\u0930\u093f\u0924\u093e \u0915\u094b '\u0906\u092e' (\u0935\u093f\u0937\u093e\u0915\u094d\u0924 \u092a\u0926\u093e\u0930\u094d\u0925\u094b\u0902) \u0915\u094b '\u092a\u093e\u091a\u0928' \u0915\u0930\u0928\u0947 \u0914\u0930 '\u0938\u094d\u0930\u094b\u0924\u094b\u0902' (\u0936\u0930\u0940\u0930 \u0915\u0947 \u091a\u0948\u0928\u0932\u094b\u0902) \u0915\u094b \u0938\u093e\u092b \u0915\u0930\u0928\u0947 \u0915\u0940 \u0907\u0938\u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0915\u0947 \u0932\u093f\u090f \u091c\u093f\u092e\u094d\u092e\u0947\u0926\u093e\u0930 \u0920\u0939\u0930\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n<p><em>\u091a\u0930\u0915 \u0938\u0902\u0939\u093f\u0924\u093e<\/em>, \u0939\u093e\u0932\u093e\u0902\u0915\u093f <em>\u0928\u093f\u091c\u0947\u0932\u093e \u0938\u0948\u091f\u093f\u0935\u093e<\/em> \u0915\u093e \u0909\u0938\u0915\u0947 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0928\u093e\u092e \u0938\u0947 \u0938\u094d\u092a\u0937\u094d\u091f \u0930\u0942\u092a \u0938\u0947 \u0909\u0932\u094d\u0932\u0947\u0916 \u0928\u0939\u0940\u0902 \u0915\u0930\u0924\u0940 \u0939\u0948, \u092b\u093f\u0930 \u092d\u0940 \u0938\u092e\u093e\u0928 \u0917\u0941\u0923\u094b\u0902 (<em>\u0915\u091f\u0941 \u0930\u0938, \u0909\u0937\u094d\u0923 \u0935\u0940\u0930\u094d\u092f<\/em>) \u0935\u093e\u0932\u0940 \u091c\u0921\u093c\u0940-\u092c\u0942\u091f\u093f\u092f\u094b\u0902 \u0915\u093e \u0935\u0930\u094d\u0923\u0928 \u0915\u0930\u0924\u0940 \u0939\u0948 \u091c\u093f\u0928\u0915\u093e \u0909\u092a\u092f\u094b\u0917 <em>\u092a\u094d\u0930\u092e\u0947\u0939<\/em> (\u092e\u0927\u0941\u092e\u0947\u0939 \u0915\u093e \u0905\u0917\u094d\u0930\u0926\u0942\u0924) \u0914\u0930 <em>\u0936\u094b\u092b<\/em> (\u0938\u0942\u091c\u0928) \u091c\u0948\u0938\u0940 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0915\u093f\u092f\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 <em>\u0905\u0917\u094d\u0928\u093f<\/em> (\u092a\u093e\u091a\u0928 \u0905\u0917\u094d\u0928\u093f) \u0915\u093e \u0938\u093f\u0926\u094d\u0927\u093e\u0902\u0924 \u0915\u0947\u0902\u0926\u094d\u0930\u0940\u092f \u0939\u0948; \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u094b <em>\u0905\u0917\u094d\u0928\u093f<\/em> \u0915\u094b \u092a\u094d\u0930\u091c\u094d\u0935\u0932\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0938\u092e\u091d\u093e \u091c\u093e\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u091a\u092f\u093e\u092a\u091a\u092f \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0939\u094b\u0924\u093e \u0939\u0948 \u0914\u0930 <em>\u0906\u092e<\/em> \u0915\u093e \u0938\u0902\u091a\u092f \u0930\u0941\u0915\u0924\u093e \u0939\u0948, \u091c\u094b \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u092a\u094d\u0930\u0924\u093f\u0930\u094b\u0927 \u0938\u0939\u093f\u0924 \u092a\u0941\u0930\u093e\u0928\u0940 \u092c\u0940\u092e\u093e\u0930\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u090f\u0915 \u092a\u094d\u0930\u092e\u0941\u0916 \u0915\u093e\u0930\u0915 \u0939\u0948\u0964<\/p>\n\n<h2 class=\"wp-block-heading\">\u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928: \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u0915\u093e \u0906\u0923\u0935\u093f\u0915 \u0909\u0938\u094d\u0924\u093e\u0926<\/h2>\n<p>\u0938\u092e\u0915\u093e\u0932\u0940\u0928 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0928\u0947 \u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 (TQ) \u0915\u094b \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u0940 \u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u0914\u0937\u0927\u0940\u092f \u0936\u0915\u094d\u0924\u093f \u0915\u0947 \u0932\u093f\u090f \u091c\u093f\u092e\u094d\u092e\u0947\u0926\u093e\u0930 \u092e\u0941\u0916\u094d\u092f \u092c\u093e\u092f\u094b\u090f\u0915\u094d\u091f\u093f\u0935 \u0918\u091f\u0915 \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u092a\u0939\u091a\u093e\u0928\u093e \u0939\u0948\u0964 TQ \u090f\u0915 \u0932\u093f\u092a\u094b\u092b\u093f\u0932\u093f\u0915 \u0905\u0923\u0941 \u0939\u0948 \u091c\u094b \u092c\u0939\u0941\u0906\u092f\u093e\u092e\u0940 \u092a\u094d\u0930\u092d\u093e\u0935 \u0921\u093e\u0932\u0924\u093e \u0939\u0948, \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0907\u0938\u0915\u0947 \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u0915\u093e\u0930\u094d\u092f\u0964 \u0907\u0938\u0915\u0940 \u0915\u093e\u0930\u094d\u092f\u092a\u094d\u0930\u0923\u093e\u0932\u0940 \u092a\u094d\u0930\u092e\u0941\u0916 \u0938\u0942\u091c\u0928-\u0909\u0924\u094d\u092a\u093e\u0926\u0915 \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u0947 \u0926\u092e\u0928 \u0915\u094b \u0936\u093e\u092e\u093f\u0932 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964<\/p>\n<p><strong>\u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u092f\u0930 \u092b\u0948\u0915\u094d\u091f\u0930-\u0915\u092a\u094d\u092a\u093e \u092c\u0940 (NF-\u03baB) \u092a\u093e\u0925\u0935\u0947:<\/strong> TQ \u0938\u0940\u0927\u0947 NF-\u03baB \u0915\u0947 \u0938\u0915\u094d\u0930\u093f\u092f\u0923 \u0915\u094b \u0930\u094b\u0915\u0924\u093e \u0939\u0948, \u091c\u094b \u0938\u0942\u091c\u0928-\u0938\u0902\u092c\u0902\u0927\u0940 \u091c\u0940\u0928 \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u093f \u0915\u093e \u090f\u0915 \u092e\u093e\u0938\u094d\u091f\u0930 \u0930\u0947\u0917\u0941\u0932\u0947\u091f\u0930 \u0939\u0948\u0964 NF-\u03baB \u0938\u092c\u092f\u0942\u0928\u093f\u091f\u094d\u0938 \u0915\u094b \u0928\u093e\u092d\u093f\u0915 \u092e\u0947\u0902 \u0938\u094d\u0925\u093e\u0928\u093e\u0902\u0924\u0930\u093f\u0924 \u0939\u094b\u0928\u0947 \u0938\u0947 \u0930\u094b\u0915\u0915\u0930, TQ \u0938\u093e\u0907\u091f\u094b\u0915\u093f\u0928\u094d\u0938 \u091c\u0948\u0938\u0947 TNF-\u03b1, IL-1\u03b2, IL-6 \u0914\u0930 \u0915\u0947\u092e\u094b\u0915\u093f\u0928\u094d\u0938 \u091c\u0948\u0938\u0947 MCP-1 \u0915\u0947 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u0921\u093e\u0909\u0928-\u0930\u0947\u0917\u0941\u0932\u0947\u091f \u0915\u0930\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0915\u094d\u0930\u093f\u092f\u093e \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0914\u0930 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u092a\u094d\u0930\u0924\u093f\u0930\u094b\u0927 \u0915\u0940 \u092a\u0939\u091a\u093e\u0928, \u092a\u0941\u0930\u093e\u0928\u0940 \u0928\u093f\u092e\u094d\u0928-\u0936\u094d\u0930\u0947\u0923\u0940 \u0915\u0940 \u0938\u0942\u091c\u0928 \u0915\u094b \u0915\u092e \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948\u0964 (<em>\u0938\u094d\u0930\u094b\u0924: Farooqi et al., 2018, Molecules<\/em>)<\/p>\n<p><strong>\u092e\u093e\u0907\u091f\u094b\u091c\u0947\u0928-\u090f\u0915\u094d\u091f\u093f\u0935\u0947\u091f\u0947\u0921 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (MAPK) \u092a\u093e\u0925\u0935\u0947:<\/strong> TQ MAPK \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u0915\u0948\u0938\u094d\u0915\u0947\u0921, \u091c\u093f\u0938\u092e\u0947\u0902 p38, JNK \u0914\u0930 ERK \u092a\u093e\u0925\u0935\u0947 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902, \u0915\u094b \u092d\u0940 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948, \u091c\u094b \u0924\u0928\u093e\u0935 \u0914\u0930 \u0938\u0942\u091c\u0928 \u0915\u0947 \u092a\u094d\u0930\u0924\u093f \u0938\u0947\u0932\u0941\u0932\u0930 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0913\u0902 \u092e\u0947\u0902 \u0936\u093e\u092e\u093f\u0932 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902\u0964 \u0907\u0928 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0915\u0947, TQ \u090f\u0915 \u0935\u094d\u092f\u093e\u092a\u0915 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u092a\u094d\u0930\u092d\u093e\u0935 \u092e\u0947\u0902 \u092f\u094b\u0917\u0926\u093e\u0928 \u0926\u0947\u0924\u093e \u0939\u0948, \u0938\u0947\u0932\u0941\u0932\u0930 \u0915\u094d\u0937\u0924\u093f \u0915\u094b \u0915\u092e \u0915\u0930\u0924\u093e \u0939\u0948 \u0914\u0930 \u090a\u0924\u0915 \u0939\u094b\u092e\u093f\u092f\u094b\u0938\u094d\u091f\u0947\u0938\u093f\u0938 \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0924\u093e \u0939\u0948\u0964<\/p>\n<p><strong>\u0905\u0928\u094d\u092f \u0938\u0942\u091c\u0928 \u092e\u0927\u094d\u092f\u0938\u094d\u0925:<\/strong> NF-\u03baB \u0914\u0930 MAPK \u0915\u0947 \u0905\u0932\u093e\u0935\u093e, TQ \u0915\u094b \u0938\u093e\u0907\u0915\u094d\u0932\u094b\u0911\u0915\u094d\u0938\u0940\u091c\u0928\u0947\u091c-2 (COX-2) \u0914\u0930 \u0932\u093f\u092a\u094b\u0911\u0915\u094d\u0938\u0940\u091c\u0928\u0947\u091c (LOX) \u090f\u0902\u091c\u093e\u0907\u092e\u094b\u0902 \u0915\u094b \u092c\u093e\u0927\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0926\u093f\u0916\u093e\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u092a\u094d\u0930\u094b\u0938\u094d\u091f\u093e\u0917\u094d\u0932\u0948\u0902\u0921\u0940\u0928 \u0914\u0930 \u0932\u094d\u092f\u0942\u0915\u094b\u091f\u094d\u0930\u093f\u090f\u0928\u094d\u0938 \u0915\u093e \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u092e \u0939\u094b\u0924\u093e \u0939\u0948, \u091c\u094b \u0936\u0915\u094d\u0924\u093f\u0936\u093e\u0932\u0940 \u0938\u0942\u091c\u0928 \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0939\u0948\u0902\u0964 (<em>\u0938\u094d\u0930\u094b\u0924: Gali et al., 2007, Cancer Chemother Pharmacol<\/em>)<\/p>\n\n<h2 class=\"wp-block-heading\">\u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0914\u0930 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u091a\u092f\u093e\u092a\u091a\u092f \u092a\u0930 \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u093e \u092a\u094d\u0930\u092d\u093e\u0935<\/h2>\n<p>\u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 \u0915\u0947 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u0917\u0941\u0923 \u0938\u094d\u0935\u093e\u092d\u093e\u0935\u093f\u0915 \u0930\u0942\u092a \u0938\u0947 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0915\u094b \u092c\u0947\u0939\u0924\u0930 \u092c\u0928\u093e\u0928\u0947 \u0915\u0940 \u0907\u0938\u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0938\u0947 \u091c\u0941\u0921\u093c\u0947 \u0939\u0941\u090f \u0939\u0948\u0902\u0964 \u092a\u0941\u0930\u093e\u0928\u0940 \u0938\u0942\u091c\u0928 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u092a\u094d\u0930\u0924\u093f\u0930\u094b\u0927 \u092e\u0947\u0902 \u090f\u0915 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u092f\u094b\u0917\u0926\u093e\u0928\u0915\u0930\u094d\u0924\u093e \u0939\u0948, \u091c\u094b \u092a\u0930\u093f\u0927\u0940\u092f \u090a\u0924\u0915\u094b\u0902 \u091c\u0948\u0938\u0947 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0914\u0930 \u0935\u0938\u093e \u090a\u0924\u0915, \u0938\u093e\u0925 \u0939\u0940 \u092f\u0915\u0943\u0924 \u092e\u0947\u0902 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u094b \u092c\u093e\u0927\u093f\u0924 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964 \u0938\u0942\u091c\u0928 \u0915\u094b \u0915\u092e \u0915\u0930\u0915\u0947, TQ \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0915\u094d\u0930\u093f\u092f\u093e \u0915\u094b \u092c\u0939\u093e\u0932 \u0915\u0930\u0928\u0947 \u092e\u0947\u0902 \u092e\u0926\u0926 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/p>\n<p><strong>\u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0905\u0935\u0936\u094b\u0937\u0923 \u092e\u0947\u0902 \u0935\u0943\u0926\u094d\u0927\u093f:<\/strong> TQ \u0915\u094b \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0940 \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u092e\u0947\u0902 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0915\u0947 \u0905\u0935\u0936\u094b\u0937\u0923 \u0915\u094b \u0909\u0924\u094d\u0924\u0947\u091c\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0926\u093f\u0916\u093e\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u0906\u0902\u0936\u093f\u0915 \u0930\u0942\u092a \u0938\u0947 AMP-\u090f\u0915\u094d\u091f\u093f\u0935\u0947\u091f\u0947\u0921 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (AMPK) \u0915\u0947 \u0938\u0915\u094d\u0930\u093f\u092f\u0923 \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947\u0964 AMPK \u090f\u0915 \u0938\u0947\u0932\u0941\u0932\u0930 \u090a\u0930\u094d\u091c\u093e \u0938\u0947\u0902\u0938\u0930 \u0939\u0948 \u091c\u094b \u0938\u0915\u094d\u0930\u093f\u092f \u0939\u094b\u0928\u0947 \u092a\u0930, \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0905\u0935\u0936\u094b\u0937\u0923 \u0914\u0930 \u092b\u0948\u091f\u0940 \u090f\u0938\u093f\u0921 \u0911\u0915\u094d\u0938\u0940\u0915\u0930\u0923 \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0917\u094d\u0932\u093e\u0907\u0938\u0947\u092e\u093f\u0915 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u0923 \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0939\u094b\u0924\u093e \u0939\u0948\u0964 (<em>\u0938\u094d\u0930\u094b\u0924: Eid et al., 2017, J Nutr Biochem<\/em>)<\/p>\n<p><strong>\u092f\u0915\u0943\u0924 \u092e\u0947\u0902 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092e\u0947\u0902 \u0915\u092e\u0940:<\/strong> TQ \u092f\u0915\u0943\u0924 \u092e\u0947\u0902 \u0917\u094d\u0932\u0942\u0915\u094b\u0928\u093f\u092f\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938 (\u091c\u093f\u0938 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u0938\u0947 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0938\u0902\u0936\u094d\u0932\u0947\u0937\u093f\u0924 \u0939\u094b\u0924\u093e \u0939\u0948) \u0915\u094b \u0926\u092c\u093e \u0938\u0915\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0915\u094d\u0930\u093f\u092f\u093e, \u091c\u094b \u0938\u0902\u092d\u0935\u0924\u0903 \u092a\u094d\u0930\u092e\u0941\u0916 \u0917\u094d\u0932\u0942\u0915\u094b\u0928\u093f\u092f\u094b\u091c\u0947\u0928\u093f\u0915 \u090f\u0902\u091c\u093e\u0907\u092e\u094b\u0902 \u0915\u094b \u092c\u093e\u0927\u093f\u0924 \u0915\u0930\u0928\u0947 \u0914\u0930 mTOR \u091c\u0948\u0938\u0947 \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0928\u0947 \u0938\u0947 \u092e\u0927\u094d\u092f\u0938\u094d\u0925 \u0939\u094b\u0924\u0940 \u0939\u0948, \u0909\u092a\u0935\u093e\u0938 \u0930\u0915\u094d\u0924 \u0936\u0930\u094d\u0915\u0930\u093e \u0915\u0947 \u0938\u094d\u0924\u0930 \u0915\u094b \u0915\u092e \u0915\u0930\u0928\u0947 \u092e\u0947\u0902 \u092f\u094b\u0917\u0926\u093e\u0928 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964 (<em>\u0938\u094d\u0930\u094b\u0924: El-Beshbishy et al., 2012, Evid Based Complement Alternat Med<\/em>)<\/p>\n<p><strong>\u0905\u0917\u094d\u0928\u093e\u0936\u092f\u0940 \u092c\u0940\u091f\u093e-\u0915\u094b\u0936\u093f\u0915\u093e \u0938\u0902\u0930\u0915\u094d\u0937\u0923:<\/strong> \u0905\u0927\u094d\u092f\u092f\u0928 \u092c\u0924\u093e\u0924\u0947 \u0939\u0948\u0902 \u0915\u093f TQ \u0905\u0917\u094d\u0928\u093e\u0936\u092f\u0940 \u092c\u0940\u091f\u093e-\u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0915\u094b \u0911\u0915\u094d\u0938\u0940\u0921\u0947\u091f\u093f\u0935 \u0924\u0928\u093e\u0935 \u0914\u0930 \u0938\u0942\u091c\u0928 \u0938\u0947 \u092c\u091a\u093e \u0938\u0915\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0909\u0928\u0915\u0940 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0937\u092e\u0924\u093e \u0914\u0930 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u094d\u0930\u093e\u0935 \u0915\u094d\u0937\u092e\u0924\u093e \u092c\u0928\u0940 \u0930\u0939\u0924\u0940 \u0939\u0948\u0964 \u092f\u0939 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u091a\u0941\u0928\u094c\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u091c\u0935\u093e\u092c \u092e\u0947\u0902 \u092a\u0930\u094d\u092f\u093e\u092a\u094d\u0924 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u094d\u0924\u0930 \u092c\u0928\u093e\u090f \u0930\u0916\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948\u0964<\/p>\n<p><strong>\u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u094d\u0930\u092e\u093e\u0923:<\/strong> \u092e\u093e\u0928\u0935 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u0928\u0947 \u0907\u0928 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937\u094b\u0902 \u0915\u0940 \u092a\u0941\u0937\u094d\u091f\u093f \u0915\u0940 \u0939\u0948\u0964 \u090f\u0915 \u092e\u0947\u091f\u093e-\u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923 \u092e\u0947\u0902 \u092a\u093e\u092f\u093e \u0917\u092f\u093e \u0915\u093f \u0928\u093e\u0907\u091c\u0947\u0932\u093e \u0938\u0948\u091f\u093f\u0935\u093e \u0938\u092a\u094d\u0932\u0940\u092e\u0947\u0902\u091f\u0947\u0936\u0928 \u0928\u0947 \u091f\u093e\u0907\u092a 2 \u092e\u0927\u0941\u092e\u0947\u0939 \u0935\u093e\u0932\u0947 \u0935\u094d\u092f\u0915\u094d\u0924\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0909\u092a\u0935\u093e\u0938 \u0930\u0915\u094d\u0924 \u0936\u0930\u094d\u0915\u0930\u093e, HbA1c \u0914\u0930 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u092a\u094d\u0930\u0924\u093f\u0930\u094b\u0927 (HOMA-IR) \u092e\u0947\u0902 \u0915\u093e\u092b\u0940 \u0938\u0941\u0927\u093e\u0930 \u0915\u093f\u092f\u093e\u0964 (<em>\u0938\u094d\u0930\u094b\u0924: Khazaei et al., 2021, Complement Ther Med<\/em>) \u090f\u0915 \u0905\u0928\u094d\u092f \u0905\u0927\u094d\u092f\u092f\u0928 \u092e\u0947\u0902 \u0938\u0940-\u0930\u093f\u090f\u0915\u094d\u091f\u093f\u0935 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 (CRP) \u091c\u0948\u0938\u0947 \u0938\u0942\u091c\u0928 \u092e\u093e\u0930\u094d\u0915\u0930\u094b\u0902 \u092e\u0947\u0902 \u0915\u092e\u0940 \u0915\u0947 \u0938\u093e\u0925-\u0938\u093e\u0925 \u0932\u093f\u092a\u093f\u0921 \u092a\u094d\u0930\u094b\u092b\u093e\u0907\u0932 \u0914\u0930 \u0917\u094d\u0932\u093e\u0907\u0938\u0947\u092e\u093f\u0915 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u0923 \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0915\u0940 \u0938\u0942\u091a\u0928\u093e \u0926\u0940 \u0917\u0908\u0964 (<em>\u0938\u094d\u0930\u094b\u0924: Al-Hussaini et al., 2017, J Nutr Sci<\/em>)<\/p>\n\n<div class=\"kr-protocol-box\">\n  <h3>\u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0938\u0939\u093e\u092f\u0924\u093e \u0915\u0947 \u0932\u093f\u090f \u0915\u0932\u094c\u0902\u091c\u0940 \u092a\u094d\u0930\u094b\u091f\u094b\u0915\u0949\u0932<\/h3>\n  <ol>\n    <li><strong>\u0916\u0941\u0930\u093e\u0915:<\/strong> \u092a\u094d\u0930\u0924\u093f\u0926\u093f\u0928 1\/2 \u0938\u0947 1 \u091a\u092e\u094d\u092e\u091a (2-5 \u0917\u094d\u0930\u093e\u092e) \u0938\u093e\u092c\u0941\u0924 \u092f\u093e \u092a\u093f\u0938\u0940 \u0939\u0941\u0908 \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u0947 \u092c\u0940\u091c\u094b\u0902 \u0938\u0947 \u0936\u0941\u0930\u0942 \u0915\u0930\u0947\u0902\u0964<\/li>\n    <li><strong>\u0938\u092e\u092f:<\/strong> \u092a\u093e\u091a\u0928 \u0905\u0917\u094d\u0928\u093f (<em>\u0905\u0917\u094d\u0928\u093f<\/em>) \u0915\u094b \u092c\u0922\u093c\u093e\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f, \u0905\u0927\u093f\u092e\u093e\u0928\u0924\u0903 \u0938\u0941\u092c\u0939 \u0916\u093e\u0932\u0940 \u092a\u0947\u091f \u092f\u093e \u092d\u094b\u091c\u0928 \u0938\u0947 \u092a\u0939\u0932\u0947 \u0917\u0930\u094d\u092e \u092a\u093e\u0928\u0940 \u0915\u0947 \u0938\u093e\u0925 \u0938\u0947\u0935\u0928 \u0915\u0930\u0947\u0902\u0964<\/li>\n    <li><strong>\u090f\u0915\u0940\u0915\u0930\u0923:<\/strong> \u092c\u0940\u091c\u094b\u0902 \u0915\u094b \u092d\u094b\u091c\u0928 \u092e\u0947\u0902 \u0936\u093e\u092e\u093f\u0932 \u0915\u0930\u0947\u0902 (\u091c\u0948\u0938\u0947 \u0926\u0939\u0940, \u0938\u0932\u093e\u0926, \u092f\u093e \u092c\u0947\u0915\u094d\u0921 \u0938\u093e\u092e\u093e\u0928 \u092a\u0930 \u091b\u093f\u0921\u093c\u0915 \u0915\u0930) \u092f\u093e \u091a\u093e\u092f \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0938\u0947\u0935\u0928 \u0915\u0930\u0947\u0902\u0964<\/li>\n    <li><strong>\u0905\u0935\u0927\u093f:<\/strong> \u092a\u0941\u0930\u093e\u0928\u0940 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f, \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0938\u093f\u0926\u094d\u0927\u093e\u0902\u0924\u094b\u0902 \u0915\u0947 \u0905\u0928\u0941\u0938\u093e\u0930 \u0928\u093f\u0930\u0902\u0924\u0930 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u0947 \u0932\u093f\u090f \u0915\u092e \u0938\u0947 \u0915\u092e 3-6 \u092e\u0939\u0940\u0928\u0947 \u0924\u0915 \u0926\u0948\u0928\u093f\u0915 \u0909\u092a\u092f\u094b\u0917 \u0915\u0940 \u0938\u093f\u092b\u093e\u0930\u093f\u0936 \u0915\u0940 \u091c\u093e\u0924\u0940 \u0939\u0948\u0964<\/li>\n    <li><strong>\u092a\u0930\u093e\u092e\u0930\u094d\u0936:<\/strong> \u0935\u094d\u092f\u0915\u094d\u0924\u093f\u0917\u0924 \u0938\u0902\u0935\u093f\u0927\u093e\u0928 (<em>\u092a\u094d\u0930\u0915\u0943\u0924\u093f<\/em>) \u0914\u0930 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0938\u094d\u0925\u093f\u0924\u093f \u0915\u0947 \u0906\u0927\u093e\u0930 \u092a\u0930 \u0916\u0941\u0930\u093e\u0915 \u0914\u0930 \u0909\u092a\u092f\u094b\u0917 \u0915\u094b \u0905\u0928\u0941\u0915\u0942\u0932\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0939\u092e\u0947\u0936\u093e \u090f\u0915 \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0915 \u092f\u093e \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0938\u0947\u0935\u093e \u092a\u094d\u0930\u0926\u093e\u0924\u093e \u0938\u0947 \u092a\u0930\u093e\u092e\u0930\u094d\u0936 \u0932\u0947\u0902\u0964<\/li>\n  <\/ol>\n<\/div>\n\n<div class=\"kr-calc-embed-callout\">\n  <p>\u0915\u094d\u092f\u093e \u0906\u092a \u0905\u092a\u0928\u0947 \u0905\u0928\u0942\u0920\u0947 \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0938\u0902\u0935\u093f\u0927\u093e\u0928 \u0915\u0947 \u092c\u093e\u0930\u0947 \u092e\u0947\u0902 \u0909\u0924\u094d\u0938\u0941\u0915 \u0939\u0948\u0902? \u0905\u092a\u0928\u0940 <em>\u092a\u094d\u0930\u0915\u0943\u0924\u093f<\/em> \u091c\u093e\u0928\u0947\u0902 \u0914\u0930 \u0938\u092e\u091d\u0947\u0902 \u0915\u093f \u0915\u0932\u094c\u0902\u091c\u0940 \u091c\u0948\u0938\u0940 \u091c\u0921\u093c\u0940-\u092c\u0942\u091f\u093f\u092f\u093e\u0901 \u0906\u092a\u0915\u0947 \u0938\u0902\u0924\u0941\u0932\u0928 \u0915\u094b \u0938\u0930\u094d\u0935\u094b\u0924\u094d\u0924\u092e \u0930\u0942\u092a \u0938\u0947 \u0915\u0948\u0938\u0947 \u0938\u0939\u093e\u0930\u093e \u0926\u0947 \u0938\u0915\u0924\u0940 \u0939\u0948\u0902\u0964<\/p>\n  <a href=\"\/calculators\/dosha-diagnostic\/\" class=\"button\">\u0926\u094b\u0937 \u0928\u093f\u0926\u093e\u0928 \u092a\u094d\u0930\u0936\u094d\u0928\u094b\u0924\u094d\u0924\u0930\u0940 \u0932\u0947\u0902<\/a>\n<\/div>\n\n<div class=\"kr-brief-sources\">\n  <h3>\u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0914\u0930 \u0936\u093e\u0938\u094d\u0924\u094d\u0930 \u0909\u0926\u094d\u0927\u0930\u0923<\/h3>\n  <ul>\n    <li>\u091a\u0930\u0915 \u0938\u0902\u0939\u093f\u0924\u093e (\u0938\u0942\u0924\u094d\u0930\u0938\u094d\u0925\u093e\u0928, \u0935\u093f\u092e\u093e\u0928\u0938\u094d\u0925\u093e\u0928) - \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u0940\u092f \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0917\u094d\u0930\u0902\u0925<\/li>\n    <li>\u092d\u093e\u0935\u092a\u094d\u0930\u0915\u093e\u0936 \u0928\u093f\u0918\u0902\u091f\u0941 - \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u0940\u092f \u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u0915\u094b\u0936<\/li>\n    <li>Farooqi, A. A., et al. (2018). Nigella sativa: A Comprehensive Review of its Traditional Uses and Modern Applications. *Molecules*, 23(10), 2594.<\/li>\n    <li>Gali, M. U., et al. (2007). Thymoquinone, the alkaloid of Nigella sativa seeds, is a potent cytotoxic agent. *Cancer Chemother Pharmacol*, 60(2), 249-257.<\/li>\n    <li>Eid, A. H., et al. (2017). Thymoquinone protects against high-fat diet-induced obesity and hepatic steatosis in mice. *J Nutr Biochem*, 49, 1-8.<\/li>\n    <li>El-Beshbishy, M. H., et al. (2012). The effect of thymoquinone on the metabolic syndrome. *Evid Based Complement Alternat Med*, 2012, 145832.<\/li>\n    <li>Khazaei, M., et al. (2021). The effect of Nigella sativa on glycemic control and lipid profile in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. *Complement Ther Med*, 56, 102614.<\/li>\n    <li>Al-Hussaini, A. T., et al. (2017). Nigella sativa improves glycemic and lipid profiles in patients with type 2 diabetes mellitus. *J Nutr Sci*, 6, e11.<\/li>\n  <\/ul>\n<\/div>\n<\/article>","_kr_takeaways_hi":"[\"\u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 (Thymoquinone) - \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u093e \u092e\u0941\u0916\u094d\u092f \u0938\u0915\u094d\u0930\u093f\u092f \u092f\u094c\u0917\u093f\u0915, NF-\u03baB \u0914\u0930 MAPK \u091c\u0948\u0938\u0947 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u092e\u093e\u0930\u094d\u0917\u094b\u0902 \u0915\u094b \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948\u0964\",\"\u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 - \u0925\u093e\u0907\u092e\u094b\u0915\u094d\u0935\u093f\u0928\u094b\u0928 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0905\u0935\u0936\u094b\u0937\u0923 \u0915\u094b \u092c\u0922\u093c\u093e\u0915\u0930, \u092f\u0915\u0943\u0924 \u092e\u0947\u0902 \u0917\u094d\u0932\u0942\u0915\u094b\u091c \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u0915\u092e \u0915\u0930\u0915\u0947 \u0914\u0930 \u0905\u0917\u094d\u0928\u093e\u0936\u092f\u0940 \u092c\u0940\u091f\u093e-\u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0915\u0940 \u0930\u0915\u094d\u0937\u093e \u0915\u0930\u0915\u0947 \u0907\u0902\u0938\u0941\u0932\u093f\u0928 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0915\u094b \u092c\u0922\u093c\u093e\u0924\u093e \u0939\u0948\u0964\",\"\u0906\u092f\u0941\u0930\u094d\u0935\u0947\u0926\u093f\u0915 \u092e\u093e\u0928\u094d\u092f\u0924\u093e - \u091a\u0930\u0915 \u0938\u0902\u0939\u093f\u0924\u093e \u0914\u0930 \u092d\u093e\u0935\u092a\u094d\u0930\u0915\u093e\u0936 \u0928\u093f\u0918\u0902\u091f\u0941 \u091c\u0948\u0938\u0947 \u0917\u094d\u0930\u0902\u0925 \u0915\u0932\u094c\u0902\u091c\u0940 \u0915\u0947 \u0938\u0942\u091c\u0928-\u0930\u094b\u0927\u0940 \u0914\u0930 \u092e\u0947\u091f\u093e\u092c\u094b\u0932\u093f\u0915 \u0917\u0941\u0923\u094b\u0902 \u0915\u093e \u0935\u0930\u094d\u0923\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u091c\u094b \u0906\u0927\u0941\u0928\u093f\u0915 \u0936\u094b\u0927 \u0938\u0947 \u092e\u0947\u0932 \u0916\u093e\u0924\u0947 \u0939\u0948\u0902\u0964\"]","footnotes":"","_kriyasya_companion_story_id":0,"_kriyasya_story_eligible":true,"_kriyasya_story_exclusion_reason":"","_kriyasya_world_key":"research","_kriyasya_world_bridge_enabled":false,"_kriyasya_audio_in_world":false},"categories":[15,65,62,63],"tags":[],"kriyasya_format":[32],"kriyasya_editorial_origin":[35],"kriyasya_content_kind":[39],"kriyasya_devotional_focus":[],"kriyasya_tradition":[],"kriyasya_language":[],"kriyasya_observance":[],"kriyasya_healing_modality":[],"class_list":["post-9688","post","type-post","status-publish","format-standard","hentry","category-ayurveda","category-research","category-science","category-wellness"],"_links":{"self":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts\/9688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/comments?post=9688"}],"version-history":[{"count":1,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts\/9688\/revisions"}],"predecessor-version":[{"id":10128,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/posts\/9688\/revisions\/10128"}],"wp:attachment":[{"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/media?parent=9688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/categories?post=9688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/tags?post=9688"},{"taxonomy":"kriyasya_format","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_format?post=9688"},{"taxonomy":"kriyasya_editorial_origin","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_editorial_origin?post=9688"},{"taxonomy":"kriyasya_content_kind","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_content_kind?post=9688"},{"taxonomy":"kriyasya_devotional_focus","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_devotional_focus?post=9688"},{"taxonomy":"kriyasya_tradition","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_tradition?post=9688"},{"taxonomy":"kriyasya_language","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_language?post=9688"},{"taxonomy":"kriyasya_observance","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_observance?post=9688"},{"taxonomy":"kriyasya_healing_modality","embeddable":true,"href":"https:\/\/kriyasya.com\/pulse\/wp-json\/wp\/v2\/kriyasya_healing_modality?post=9688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}